Familial Risk of Renal Cell Cancer and Interaction with Obesity and Hyperglycemia: A Population-Based Study
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lee, Sung Won | - |
dc.contributor.author | Kim, Hyun Jung | - |
dc.contributor.author | Kazmi, Sayada Zartasha | - |
dc.contributor.author | Choi, Yoon Jung | - |
dc.contributor.author | Hong, Gahwi | - |
dc.contributor.author | Kim, Young Shin | - |
dc.contributor.author | Swan, Heather | - |
dc.contributor.author | Cha, Jaewoo | - |
dc.contributor.author | Kang, Taeuk | - |
dc.contributor.author | Hann, Hoo Jae | - |
dc.contributor.author | Ahn, Hyeong Sik | - |
dc.date.accessioned | 2022-08-10T13:40:19Z | - |
dc.date.available | 2022-08-10T13:40:19Z | - |
dc.date.created | 2022-08-10 | - |
dc.date.issued | 2022-08 | - |
dc.identifier.issn | 0022-5347 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142740 | - |
dc.description.abstract | Purpose: We quantified the familial risk of renal cell cancer (RCC) among firstdegree relatives (FDRs) on a population level, and examined interactions between family history and body mass index or blood glucose. Materials and Methods: Using the National Health Insurance database, which covers the entire Korean population, and the National Health Screening Program, we constructed a cohort of 5,524,403 individuals with blood-related FDRs and their lifestyle factors from 2002 to 2018. We calculated familial risk using incidence risk ratios (IRRs) with 95% confidence intervals, which compares the risk of individuals with and without FDR. The combined effect and interaction of a given risk factor and family history of RCC were measured by the relative excess risk due to interaction. Results: Individuals with affected FDRs showed a 2.29-fold (95% CI 1.68-3.13) increased risk of disease. Familial risk adjusted for lifestyle factors showed minimal attenuation (IRR 2.25; 95% CI: 1.65-3.08), suggesting that genetic predisposition is the main contributor in the familial aggregation of RCC. Individuals with both a positive family history and overweight/obesity (IRR 3.71, 95% CI 2.50-4.92) or hyperglycemia (IRR 4.52, 95% CI 2.59-6.45) had a significantly higher risk that exceeded the sum of their individual risks, suggesting an interaction that was statistically significant (relative excess risk due to interaction 95% CI: 0.91, -0.21-2.12; 2.21, 0.28-4.14). Conclusions: Our findings suggest an interaction between genetic and environmental factors, namely obesity and hyperglycemia. Individuals with both factors should be considered a high-risk group and advised to undergo genetic counseling. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject | KIDNEY-CANCER | - |
dc.subject | CARCINOMA | - |
dc.subject | HISTORY | - |
dc.title | Familial Risk of Renal Cell Cancer and Interaction with Obesity and Hyperglycemia: A Population-Based Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Ahn, Hyeong Sik | - |
dc.identifier.doi | 10.1097/JU.0000000000002506 | - |
dc.identifier.scopusid | 2-s2.0-85134342294 | - |
dc.identifier.wosid | 000823292100010 | - |
dc.identifier.bibliographicCitation | JOURNAL OF UROLOGY, v.208, no.2, pp.251 - + | - |
dc.relation.isPartOf | JOURNAL OF UROLOGY | - |
dc.citation.title | JOURNAL OF UROLOGY | - |
dc.citation.volume | 208 | - |
dc.citation.number | 2 | - |
dc.citation.startPage | 251 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Urology & Nephrology | - |
dc.relation.journalWebOfScienceCategory | Urology & Nephrology | - |
dc.subject.keywordPlus | KIDNEY-CANCER | - |
dc.subject.keywordPlus | CARCINOMA | - |
dc.subject.keywordPlus | HISTORY | - |
dc.subject.keywordAuthor | carcinoma | - |
dc.subject.keywordAuthor | renal cell | - |
dc.subject.keywordAuthor | gene-environment interaction | - |
dc.subject.keywordAuthor | obesity | - |
dc.subject.keywordAuthor | hyperglycemia | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.