Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Cheol Gyu | - |
dc.contributor.author | Choi, Sang-Hun | - |
dc.contributor.author | Lee, Seon Yong | - |
dc.contributor.author | Eun, Kiyoung | - |
dc.contributor.author | Park, Min Gi | - |
dc.contributor.author | Jang, Junseok | - |
dc.contributor.author | Jeong, Hyeon Ju | - |
dc.contributor.author | Kim, Seong Jin | - |
dc.contributor.author | Jeong, Sohee | - |
dc.contributor.author | Lee, Kanghun | - |
dc.contributor.author | Kim, Hyunggee | - |
dc.date.accessioned | 2022-08-10T18:44:10Z | - |
dc.date.available | 2022-08-10T18:44:10Z | - |
dc.date.created | 2022-08-10 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2073-4409 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142766 | - |
dc.description.abstract | The oncogenic role of nuclear LIM domain only 2 (LMO2) as a transcriptional regulator is well established, but its function in the cytoplasm is largely unknown. Here, we identified LMO2 as a cytoplasmic activator for signal transducer and activator of transcription 3 (STAT3) signaling in glioma stem cells (GSCs) through biochemical and bioinformatics analyses. LMO2 increases STAT3 phosphorylation by interacting with glycoprotein 130 (gp130) and Janus kinases (JAKs). LMO2-driven activation of STAT3 signaling requires the LDB1 protein and leads to increased expression of an inhibitor of differentiation 1 (ID1), a master regulator of cancer stemness. Our findings indicate that the cytoplasmic LMO2-LDB1 complex plays a crucial role in the activation of the GSC signaling cascade via interaction with gp130 and JAK1/2. Thus, LMO2-LDB1 is a bona fide oncogenic protein complex that activates either the JAK-STAT signaling cascade in the cytoplasm or direct transcriptional regulation in the nucleus. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | MALIGNANT GLIOMAS | - |
dc.subject | GLIOBLASTOMA | - |
dc.subject | EXPRESSION | - |
dc.subject | LMO2 | - |
dc.subject | IDENTIFICATION | - |
dc.subject | HETEROGENEITY | - |
dc.subject | LEUKEMIA | - |
dc.subject | BINDING | - |
dc.subject | GROWTH | - |
dc.subject | GENE | - |
dc.title | Cytoplasmic LMO2-LDB1 Complex Activates STAT3 Signaling through Interaction with gp130-JAK in Glioma Stem Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Hyunggee | - |
dc.identifier.doi | 10.3390/cells11132031 | - |
dc.identifier.scopusid | 2-s2.0-85132812436 | - |
dc.identifier.wosid | 000825570700001 | - |
dc.identifier.bibliographicCitation | CELLS, v.11, no.13 | - |
dc.relation.isPartOf | CELLS | - |
dc.citation.title | CELLS | - |
dc.citation.volume | 11 | - |
dc.citation.number | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | MALIGNANT GLIOMAS | - |
dc.subject.keywordPlus | GLIOBLASTOMA | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | LMO2 | - |
dc.subject.keywordPlus | IDENTIFICATION | - |
dc.subject.keywordPlus | HETEROGENEITY | - |
dc.subject.keywordPlus | LEUKEMIA | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | GROWTH | - |
dc.subject.keywordPlus | GENE | - |
dc.subject.keywordAuthor | cancer stem cells | - |
dc.subject.keywordAuthor | glioblastoma | - |
dc.subject.keywordAuthor | glioma stem cells | - |
dc.subject.keywordAuthor | LMO2 | - |
dc.subject.keywordAuthor | STAT3 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.