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The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Asiimwe, Nicholas | - |
| dc.contributor.author | Al Mazid, Mohammad Faysal | - |
| dc.contributor.author | Jeong, Yong Taek | - |
| dc.contributor.author | Lee, Juyong | - |
| dc.contributor.author | Lee, Jun-Seok | - |
| dc.date.accessioned | 2022-08-10T23:40:56Z | - |
| dc.date.available | 2022-08-10T23:40:56Z | - |
| dc.date.created | 2022-08-10 | - |
| dc.date.issued | 2022-06-22 | - |
| dc.identifier.issn | 2046-2069 | - |
| dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142793 | - |
| dc.description.abstract | The formylglycine-generating enzyme is a key regulator that converts sulfatase into an active form. Despite its key role in many diseases, enzyme activity inhibitors have not yet been reported. In this study, we investigated penta-peptide ligands for FGE activity inhibition and discovered two hit peptides. In addition, the lead peptides also showed potential antibacterial effects in a Mycobacterium tuberculosis model. | - |
| dc.language | English | - |
| dc.language.iso | en | - |
| dc.publisher | ROYAL SOC CHEMISTRY | - |
| dc.subject | MOUSE MODEL | - |
| dc.subject | SULFATASES | - |
| dc.subject | INTERFACE | - |
| dc.title | The discovery of penta-peptides inhibiting the activity of the formylglycine-generating enzyme and their potential antibacterial effects against Mycobacterium tuberculosis | - |
| dc.type | Article | - |
| dc.contributor.affiliatedAuthor | Jeong, Yong Taek | - |
| dc.contributor.affiliatedAuthor | Lee, Jun-Seok | - |
| dc.identifier.doi | 10.1039/d2ra03379h | - |
| dc.identifier.scopusid | 2-s2.0-85134341828 | - |
| dc.identifier.wosid | 000818027200001 | - |
| dc.identifier.bibliographicCitation | RSC ADVANCES, v.12, no.29, pp.18884 - 18888 | - |
| dc.relation.isPartOf | RSC ADVANCES | - |
| dc.citation.title | RSC ADVANCES | - |
| dc.citation.volume | 12 | - |
| dc.citation.number | 29 | - |
| dc.citation.startPage | 18884 | - |
| dc.citation.endPage | 18888 | - |
| dc.type.rims | ART | - |
| dc.type.docType | Article | - |
| dc.description.journalClass | 1 | - |
| dc.description.isOpenAccess | Y | - |
| dc.description.journalRegisteredClass | scie | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.relation.journalResearchArea | Chemistry | - |
| dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
| dc.subject.keywordPlus | MOUSE MODEL | - |
| dc.subject.keywordPlus | SULFATASES | - |
| dc.subject.keywordPlus | INTERFACE | - |
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