Submolecular Ligand Size and Spacing for Cell Adhesion
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Yuri | - |
dc.contributor.author | Koo, Thomas Myeongseok | - |
dc.contributor.author | Thangam, Ramar | - |
dc.contributor.author | Kim, Myeong Soo | - |
dc.contributor.author | Jang, Woo Young | - |
dc.contributor.author | Kang, Nayeon | - |
dc.contributor.author | Min, Sunhong | - |
dc.contributor.author | Kim, Seong Yeol | - |
dc.contributor.author | Yang, Letao | - |
dc.contributor.author | Hong, Hyunsik | - |
dc.contributor.author | Jung, Hee Joon | - |
dc.contributor.author | Koh, Eui Kwan | - |
dc.contributor.author | Patel, Kapil D. | - |
dc.contributor.author | Lee, Sungkyu | - |
dc.contributor.author | Fu, Hong En | - |
dc.contributor.author | Jeon, Yoo Sang | - |
dc.contributor.author | Park, Bum Chul | - |
dc.contributor.author | Kim, Soo Young | - |
dc.contributor.author | Park, Steve | - |
dc.contributor.author | Lee, Junmin | - |
dc.contributor.author | Gu, Luo | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Lee, Ki-Bum | - |
dc.contributor.author | Jeong, Woong Kyo | - |
dc.contributor.author | Paulmurugan, Ramasamy | - |
dc.contributor.author | Kim, Young Keun | - |
dc.contributor.author | Kang, Heemin | - |
dc.date.accessioned | 2022-08-12T13:41:08Z | - |
dc.date.available | 2022-08-12T13:41:08Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 0935-9648 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142914 | - |
dc.description.abstract | Cell adhesion occurs when integrin recognizes and binds to Arg-Gly-Asp (RGD) ligands present in fibronectin. In this work, submolecular ligand size and spacing are tuned via template-mediated in situ growth of nanoparticles for dynamic macrophage modulation. To tune liganded gold nanoparticle (GNP) size and spacing from 3 to 20 nm, in situ localized assemblies of GNP arrays on nanomagnetite templates are engineered. 3 nm-spaced ligands stimulate the binding of integrin, which mediates macrophage-adhesion-assisted pro-regenerative polarization as compared to 20 nm-spaced ligands, which can be dynamically anchored to the substrate for stabilizing integrin binding and facilitating dynamic macrophage adhesion. Increasing the ligand size from 7 to 20 nm only slightly promotes macrophage adhesion, not observed with 13 nm-sized ligands. Increasing the ligand spacing from 3 to 17 nm significantly hinders macrophage adhesion that induces inflammatory polarization. Submolecular tuning of ligand spacing can dominantly modulate host macrophages. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | FIBRONECTIN | - |
dc.subject | MODULATION | - |
dc.subject | RGD | - |
dc.subject | POLARIZATION | - |
dc.subject | INFLAMMATION | - |
dc.subject | BEHAVIOR | - |
dc.subject | IMPACT | - |
dc.title | Submolecular Ligand Size and Spacing for Cell Adhesion | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Woo Young | - |
dc.contributor.affiliatedAuthor | Kim, Soo Young | - |
dc.contributor.affiliatedAuthor | Jeong, Woong Kyo | - |
dc.contributor.affiliatedAuthor | Kim, Young Keun | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.identifier.doi | 10.1002/adma.202110340 | - |
dc.identifier.scopusid | 2-s2.0-85130995750 | - |
dc.identifier.wosid | 000803040700001 | - |
dc.identifier.bibliographicCitation | ADVANCED MATERIALS, v.34, no.27 | - |
dc.relation.isPartOf | ADVANCED MATERIALS | - |
dc.citation.title | ADVANCED MATERIALS | - |
dc.citation.volume | 34 | - |
dc.citation.number | 27 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | FIBRONECTIN | - |
dc.subject.keywordPlus | MODULATION | - |
dc.subject.keywordPlus | RGD | - |
dc.subject.keywordPlus | POLARIZATION | - |
dc.subject.keywordPlus | INFLAMMATION | - |
dc.subject.keywordPlus | BEHAVIOR | - |
dc.subject.keywordPlus | IMPACT | - |
dc.subject.keywordAuthor | cell adhesion | - |
dc.subject.keywordAuthor | ligand size | - |
dc.subject.keywordAuthor | ligand spacing | - |
dc.subject.keywordAuthor | macrophage modulation | - |
dc.subject.keywordAuthor | nanoassemblies | - |
dc.subject.keywordAuthor | submolecular ligands | - |
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