Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yu, Le | - |
dc.contributor.author | Xu, Yunjie | - |
dc.contributor.author | Pu, Zhongji | - |
dc.contributor.author | Kang, Heemin | - |
dc.contributor.author | Li, Mingle | - |
dc.contributor.author | Sessler, Jonathan L. | - |
dc.contributor.author | Kim, Jong Seung | - |
dc.date.accessioned | 2022-08-12T19:40:20Z | - |
dc.date.available | 2022-08-12T19:40:20Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-06-29 | - |
dc.identifier.issn | 0002-7863 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142940 | - |
dc.description.abstract | Pyroptosis, a newly characterized form of immunogenic cell death, is attracting increasing attention as a promising approach to cancer immunotherapy. However, biocompatible strategies to activate pyroptosis remain rare. Here, we show that a photocatalytic superoxide radical (O-2(-center dot)) generator, NI-TA, triggers pyroptosis in cancer cells. NI-TA was designed to take advantage of an intramolecular triplet-ground state splitting energy modulation approach. Detailed studies revealed that the pyroptosis triggered by NI-TA under conditions of photoexcitation proceeds through a caspase-3/gasdermin E (GSDME) pathway rather than via canonical processes involving caspase-1/gasdermin-D (GSDMD). NI-TA was found to function via a partial-O-2-recycling mode of action and to trigger cell pyroptosis and provide for effective cancer cell ablation even under conditions of hypoxia (<= 2% O-2). In the case of T47D 3D multicellular spheroids, good antitumor efficiency and stemness inhibition are achieved. This work highlights how photocatalytic chemistry may be leveraged to develop effective pyroptosis-inducing agents. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | PHOTODYNAMIC THERAPY | - |
dc.subject | SINGLET OXYGEN | - |
dc.subject | PHOTOSENSITIZERS | - |
dc.subject | HYPOXIA | - |
dc.subject | APOPTOSIS | - |
dc.subject | CLEAVAGE | - |
dc.subject | OXIDE | - |
dc.title | Photocatalytic Superoxide Radical Generator that Induces Pyroptosis in Cancer Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.contributor.affiliatedAuthor | Kim, Jong Seung | - |
dc.identifier.doi | 10.1021/jacs.2c03256 | - |
dc.identifier.scopusid | 2-s2.0-85133144166 | - |
dc.identifier.wosid | 000819237000001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, v.144, no.25, pp.11326 - 11337 | - |
dc.relation.isPartOf | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.title | JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | - |
dc.citation.volume | 144 | - |
dc.citation.number | 25 | - |
dc.citation.startPage | 11326 | - |
dc.citation.endPage | 11337 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | PHOTODYNAMIC THERAPY | - |
dc.subject.keywordPlus | SINGLET OXYGEN | - |
dc.subject.keywordPlus | PHOTOSENSITIZERS | - |
dc.subject.keywordPlus | HYPOXIA | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | OXIDE | - |
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