Precisely Localized Bone Regeneration Mediated by Marine-Derived Microdroplets with Superior BMP-2 Binding Affinity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Eun Young | - |
dc.contributor.author | Um, Seung-Hoon | - |
dc.contributor.author | Park, Jaeho | - |
dc.contributor.author | Jung, Youngmee | - |
dc.contributor.author | Cheon, Cheol-Hong | - |
dc.contributor.author | Jeon, Hojeong | - |
dc.contributor.author | Chung, Justin J. | - |
dc.date.accessioned | 2022-08-13T05:40:54Z | - |
dc.date.available | 2022-08-13T05:40:54Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-06 | - |
dc.identifier.issn | 1613-6810 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/142997 | - |
dc.description.abstract | Prompt and robust bone regeneration has been clinically achieved using supraphysiological doses of bone morphogenetic protein-2 (BMP-2) to overcome the short half-life and rapid clearance. However, uncontrolled burst release of exogenous BMP-2 causes severe complications such as heterotopic ossification and soft tissue inflammation. Therefore, numerous researches have focused on developing a new BMP-2 delivery system for a sustained release profile by immobilizing BMP-2 in various polymeric vehicles. Herein, to avoid denaturation of BMP-2 and enhance therapeutic action via localized delivery, a complex coacervate consisting of fucoidan, a marine-derived glycosaminoglycan, and poly-l-lysine (PLL) is fabricated. Superior BMP-2 binding ability and electrostatic interaction-driven engulfment enable facile and highly efficient microencapsulation of BMP-2. The microencapsulation ability of the coacervate significantly improves BMP-2 bioactivity and provides protection against antagonist and proteolysis, while allowing prolonged release. Moreover, BMP-2 containing coacervate is coated on conventional collagen sponges. The bioactivity and localized bone regenerating ability are confirmed through in vitro (human-derived stem cells), and in vivo (calvarial bone defect model) evaluations. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | WILEY-V C H VERLAG GMBH | - |
dc.subject | MORPHOGENETIC PROTEIN-2 | - |
dc.subject | COLLAGEN SPONGE | - |
dc.subject | IN-VITRO | - |
dc.subject | HEPARIN | - |
dc.subject | OSTEOBLAST | - |
dc.subject | DELIVERY | - |
dc.subject | RHBMP-2 | - |
dc.subject | DIFFERENTIATION | - |
dc.subject | EXPRESSION | - |
dc.subject | COMPLEXES | - |
dc.title | Precisely Localized Bone Regeneration Mediated by Marine-Derived Microdroplets with Superior BMP-2 Binding Affinity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cheon, Cheol-Hong | - |
dc.contributor.affiliatedAuthor | Jeon, Hojeong | - |
dc.identifier.doi | 10.1002/smll.202200416 | - |
dc.identifier.scopusid | 2-s2.0-85129870366 | - |
dc.identifier.wosid | 000793346800001 | - |
dc.identifier.bibliographicCitation | SMALL, v.18, no.24 | - |
dc.relation.isPartOf | SMALL | - |
dc.citation.title | SMALL | - |
dc.citation.volume | 18 | - |
dc.citation.number | 24 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalResearchArea | Physics | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Physical | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.relation.journalWebOfScienceCategory | Physics, Applied | - |
dc.relation.journalWebOfScienceCategory | Physics, Condensed Matter | - |
dc.subject.keywordPlus | MORPHOGENETIC PROTEIN-2 | - |
dc.subject.keywordPlus | COLLAGEN SPONGE | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | HEPARIN | - |
dc.subject.keywordPlus | OSTEOBLAST | - |
dc.subject.keywordPlus | DELIVERY | - |
dc.subject.keywordPlus | RHBMP-2 | - |
dc.subject.keywordPlus | DIFFERENTIATION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | COMPLEXES | - |
dc.subject.keywordAuthor | bone morphogenetic protein-2 | - |
dc.subject.keywordAuthor | complex coacervates | - |
dc.subject.keywordAuthor | fucoidan | - |
dc.subject.keywordAuthor | localized bone regeneration | - |
dc.subject.keywordAuthor | therapeutic protein delivery | - |
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