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Chemical Probes and Activity-Based Protein Profiling for Cancer Researchopen access

Authors
Al Mazid, Mohammad FaysalPark, Seung BinCheekatla, Subba RaoMurale, Dhiraj P.Shin, Kyung HoLee, Jun-Seok
Issue Date
6월-2022
Publisher
MDPI
Keywords
activity-based probe; near-infrared probe; photodynamic therapy
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.11
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
23
Number
11
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/143027
DOI
10.3390/ijms23115936
ISSN
1661-6596
Abstract
Chemical probes can be used to understand the complex biological nature of diseases. Due to the diversity of cancer types and dynamic regulatory pathways involved in the disease, there is a need to identify signaling pathways and associated proteins or enzymes that are traceable or detectable in tests for cancer diagnosis and treatment. Currently, fluorogenic chemical probes are widely used to detect cancer-associated proteins and their binding partners. These probes are also applicable in photodynamic therapy to determine drug efficacy and monitor regulating factors. In this review, we discuss the synthesis of chemical probes for different cancer types from 2016 to the present time and their application in monitoring the activity of transferases, hydrolases, deacetylases, oxidoreductases, and immune cells. Moreover, we elaborate on their potential roles in photodynamic therapy.
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