UPF1 promotes rapid degradation of m(6)A-containing RNAs
DC Field | Value | Language |
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dc.contributor.author | Boo, Sung Ho | - |
dc.contributor.author | Ha, Hongseok | - |
dc.contributor.author | Lee, Yujin | - |
dc.contributor.author | Shin, Min-Kyung | - |
dc.contributor.author | Lee, Sena | - |
dc.contributor.author | Kim, Yoon Ki | - |
dc.date.accessioned | 2022-08-13T15:40:56Z | - |
dc.date.available | 2022-08-13T15:40:56Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-05-24 | - |
dc.identifier.issn | 2211-1247 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143047 | - |
dc.description.abstract | N-6-methyladenosine (m(6)A) is the most prevalent internal modification in eukaryotic mRNAs and affects RNA processing and metabolism. When YTHDF2, an m(6)A-recognizing protein, binds to m(6)A, it facilitates the destabilization of m(6)A-containing RNAs (m(6)A RNAs). Here, we demonstrate that upstream frameshift 1 (UPF1), a key factor for nonsense-mediated mRNA decay, interacts with YTHDF2, thereby triggering rapid degradation of m(6)A RNAs. The UPF1-mediated m(6)A RNA degradation depends on a specific interaction between UPF1 and N-terminal residues 101-168 of YTHDF2. UPF1 ATPase/helicase activities, and UPF1 interaction with proline-rich nuclear receptor coactivator 2 (PNRC2), a decapping-promoting factor preferentially involved in nonsense-mediated mRNA decay. Furthermore, transcriptome-wide analyses show that YTHDF2-bound mRNAs that are not substrates for HRSP12-RNase P/MRP-mediated endoribonucleolytic cleavage are destabilized with a higher dependency on UPF1. Collectively, our data indicate dynamic and multilayered regulation of the stability of m(6)A RNAs and highlight the multifaceted role of UPF1 in mRNA decay. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.subject | STRUCTURAL BASIS | - |
dc.subject | MESSENGER-RNAS | - |
dc.subject | YTH DOMAIN | - |
dc.subject | TRANSLATION | - |
dc.subject | BINDING | - |
dc.subject | PROTEIN | - |
dc.subject | DECAY | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | SURVEILLANCE | - |
dc.subject | REVEALS | - |
dc.title | UPF1 promotes rapid degradation of m(6)A-containing RNAs | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yoon Ki | - |
dc.identifier.doi | 10.1016/j.celrep.2022.110861 | - |
dc.identifier.scopusid | 2-s2.0-85130583577 | - |
dc.identifier.wosid | 000804638200003 | - |
dc.identifier.bibliographicCitation | CELL REPORTS, v.39, no.8 | - |
dc.relation.isPartOf | CELL REPORTS | - |
dc.citation.title | CELL REPORTS | - |
dc.citation.volume | 39 | - |
dc.citation.number | 8 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cell Biology | - |
dc.relation.journalWebOfScienceCategory | Cell Biology | - |
dc.subject.keywordPlus | STRUCTURAL BASIS | - |
dc.subject.keywordPlus | MESSENGER-RNAS | - |
dc.subject.keywordPlus | YTH DOMAIN | - |
dc.subject.keywordPlus | TRANSLATION | - |
dc.subject.keywordPlus | BINDING | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | DECAY | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | SURVEILLANCE | - |
dc.subject.keywordPlus | REVEALS | - |
dc.subject.keywordAuthor | CP: Molecular biology | - |
dc.subject.keywordAuthor | m6A | - |
dc.subject.keywordAuthor | mRNA degradation | - |
dc.subject.keywordAuthor | N6-methyladenosine | - |
dc.subject.keywordAuthor | nonsense-mediated mRNA decay | - |
dc.subject.keywordAuthor | PNRC2 | - |
dc.subject.keywordAuthor | RNA modification | - |
dc.subject.keywordAuthor | UPF1 | - |
dc.subject.keywordAuthor | YTHDF2 | - |
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