In vitro synergistic antimicrobial activity of a combination of meropenem, colistin, tigecycline, rifampin, and ceftolozane/tazobactam against carbapenem-resistant Acinetobacter baumannii
DC Field | Value | Language |
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dc.contributor.author | Ju, Yong Guk | - |
dc.contributor.author | Lee, Hak Joon | - |
dc.contributor.author | Yim, Hong Soon | - |
dc.contributor.author | Lee, Min-Goo | - |
dc.contributor.author | Sohn, Jang Wook | - |
dc.contributor.author | Yoon, Young Kyung | - |
dc.date.accessioned | 2022-08-13T19:40:43Z | - |
dc.date.available | 2022-08-13T19:40:43Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-05-09 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143066 | - |
dc.description.abstract | We investigated the in vitro activity of various antimicrobial combinations against carbapenem-resistant Acinetobacter baumannii (CRAB) isolates. The in vitro activity of six two-drug combinations against CRAB isolates collected from the blood samples of patients with bloodstream infection was evaluated using the checkerboard method and time-kill assay [0.5 x, 1 x, and 2 x minimum inhibitory concentration (MIC)] to identify potential synergistic and bactericidal two-drug combinations against CRAB isolates. The effects of meropenem, colistin, tigecycline, rifampin, and ceftolozane/tazobactam combinations were investigated. All 10 CRAB isolates in our study produced the OXA-58-type and OXA-23-type carbapenem-hydrolyzing oxacillinases. The colistin-ceftolozane/tazobactam combination showed synergistic effects in both the time-kill assay (using an antibiotic concentration of 1 x MIC) and the checkerboard method. It also showed bactericidal effects in the time-kill assay. For all 10 CRAB isolates, time-kill curves showed synergistic bactericidal activity of the colistin-ceftolozane/tazobactam combination at 0.5 x MIC. Overall, there was substantial discordance of synergistic activity between the checkerboard microdilution and time-kill assays (with a concordance of 31.7%). Our study demonstrated that two-drug combinations of colistin and ceftolozane/tazobactam could be useful treatment alternatives for CRAB infections. The effects of these antibiotic combinations should be evaluated using in vivo experimental models. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.subject | EXTENSIVELY DRUG-RESISTANT | - |
dc.subject | TIME-KILL | - |
dc.subject | ANTIBIOTIC SYNERGY | - |
dc.subject | PSEUDOMONAS-AERUGINOSA | - |
dc.subject | CHECKERBOARD | - |
dc.subject | METAANALYSIS | - |
dc.subject | POLYMYXINS | - |
dc.subject | EMERGENCE | - |
dc.subject | MORTALITY | - |
dc.subject | DORIPENEM | - |
dc.title | In vitro synergistic antimicrobial activity of a combination of meropenem, colistin, tigecycline, rifampin, and ceftolozane/tazobactam against carbapenem-resistant Acinetobacter baumannii | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Min-Goo | - |
dc.contributor.affiliatedAuthor | Yoon, Young Kyung | - |
dc.identifier.doi | 10.1038/s41598-022-11464-6 | - |
dc.identifier.scopusid | 2-s2.0-85129474646 | - |
dc.identifier.wosid | 000792845300048 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.12, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | EXTENSIVELY DRUG-RESISTANT | - |
dc.subject.keywordPlus | TIME-KILL | - |
dc.subject.keywordPlus | ANTIBIOTIC SYNERGY | - |
dc.subject.keywordPlus | PSEUDOMONAS-AERUGINOSA | - |
dc.subject.keywordPlus | CHECKERBOARD | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | POLYMYXINS | - |
dc.subject.keywordPlus | EMERGENCE | - |
dc.subject.keywordPlus | MORTALITY | - |
dc.subject.keywordPlus | DORIPENEM | - |
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