Platelet Function and Genotype after DES Implantation in East Asian Patients: Rationale and Characteristics of the PTRG-DES Consortium
DC Field | Value | Language |
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dc.contributor.author | Her, Ae-Young | - |
dc.contributor.author | Jeong, Young-Hoon | - |
dc.contributor.author | Kim, Byeong-Keuk | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Chang, Kiyuk | - |
dc.contributor.author | Park, Yongwhi | - |
dc.contributor.author | Song, Young Bin | - |
dc.contributor.author | Ahn, Sung Gyun | - |
dc.contributor.author | Suh, Jung-Won | - |
dc.contributor.author | Lee, Sang Yeup | - |
dc.contributor.author | Cho, Jung Rae | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.contributor.author | Kim, Moo Hyun | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.date.accessioned | 2022-08-13T22:40:42Z | - |
dc.date.available | 2022-08-13T22:40:42Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0513-5796 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143081 | - |
dc.description.abstract | Purpose: Platelet function test (PFT) results and genotype hold unique prognostic implications in East Asian patients. The aim of the PTRG-DES (Platelet function and genoType-Related long-term proGnosis in Drug-Eluting Stent-treated Patients with coronary artery disease) consortium is to assess the clinical impact thereof on long-term clinical outcomes in Korean patients with coronary artery disease during dual antiplatelet therapy (DAPT) including clopidogrel. Materials and Methods: Searching publications on the PubMed, we reviewed clopidogrel treatment studies with PFT and/or genotype data for potential inclusion in this study. Lead investigators were invited to share PFT/genotype results, patient characteristics, and clinical outcomes to evaluate relationships among them. Results: Nine registries from 32 academic centers participated in the PTRG-DES consortium, contributing individual patient data from 13160 patients who underwent DES implantation between July 2003 and August 2018. The PTRG-PFT cohort was composed of 11714 patients with available VerifyNow assay results. Platelet reactivity levels reached 218 +/- 79 P2Y12 reaction units (PRU), and high on-clopidogrel platelet reactivity based on a consensus-recommended cutoff (PRU >208) was observed in 55.9%. The PTRGGenotype cohort consisted of 8163 patients with candidate genotypes related with clopidogrel responsiveness. Of those with cytochrome P450 (CYP) 2C19 genotype, frequencies of carrying one and two loss-of-function allele (s) (*2 or *3) were 47.9% (intermediate metabolizers) and 14.2% (poor metabolizers), respectively. Conclusion: The PTRG-DES consortium highlights unique values for on-clopidogrel platelet reactivity and CYP2C19 phenotype that may be important to developing optimal antiplatelet regimens in East Asian patients. Trial Registration: ClinicalTrials.gov Identifier: NCT04734028. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | YONSEI UNIV COLL MEDICINE | - |
dc.subject | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject | DUAL ANTIPLATELET THERAPY | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | FOCUSED UPDATE | - |
dc.subject | CLOPIDOGREL | - |
dc.subject | TICAGRELOR | - |
dc.title | Platelet Function and Genotype after DES Implantation in East Asian Patients: Rationale and Characteristics of the PTRG-DES Consortium | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lim, Do-Sun | - |
dc.identifier.doi | 10.3349/ymj.2022.63.5.413 | - |
dc.identifier.scopusid | 2-s2.0-85129925147 | - |
dc.identifier.wosid | 000798316200002 | - |
dc.identifier.bibliographicCitation | YONSEI MEDICAL JOURNAL, v.63, no.5, pp.413 - 421 | - |
dc.relation.isPartOf | YONSEI MEDICAL JOURNAL | - |
dc.citation.title | YONSEI MEDICAL JOURNAL | - |
dc.citation.volume | 63 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 413 | - |
dc.citation.endPage | 421 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002833148 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | PERCUTANEOUS CORONARY INTERVENTION | - |
dc.subject.keywordPlus | ACUTE MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | DUAL ANTIPLATELET THERAPY | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | FOCUSED UPDATE | - |
dc.subject.keywordPlus | CLOPIDOGREL | - |
dc.subject.keywordPlus | TICAGRELOR | - |
dc.subject.keywordAuthor | East Asia | - |
dc.subject.keywordAuthor | platelet function | - |
dc.subject.keywordAuthor | genotype | - |
dc.subject.keywordAuthor | drug-eluting stent | - |
dc.subject.keywordAuthor | coronary artery disease | - |
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