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Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Strokeopen accessFasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke

Other Titles
Fasting and Non-Fasting Triglycerides in Patients With Acute Ischemic Stroke
Authors
Kim, Jun YupLee, Keon-JooKang, JihoonKim, Beom JoonHan, Moon-KuKang, KyusikPark, Jong-MooPark, Tai HwanPark, Hong-KyunCho, Yong-JinHong, Keun-SikLee, Kyung BokJang, Myung SukLee, Ji SungLee, JuneyoungBae, Hee-Joon
Issue Date
4-4월-2022
Publisher
KOREAN ACAD MEDICAL SCIENCES
Keywords
Triglycerides; Postprandial; Fasting Triglycerides; Non-fasting Triglycerides; Ischemic Stroke
Citation
JOURNAL OF KOREAN MEDICAL SCIENCE, v.37, no.13, pp.1 - 11
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF KOREAN MEDICAL SCIENCE
Volume
37
Number
13
Start Page
1
End Page
11
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/143101
DOI
10.3346/jkms.2022.37.e100
ISSN
1011-8934
Abstract
Background: Clinical implications of elevated fasting triglycerides (FTGs) and non-fasting triglycerides (NFTGs) in acute ischemic stroke (AIS) remain unknown. We aimed to elucidate the correlation and clinical significance of FTG and NFTG levels in AIS patients. Methods: Using a multicenter prospective stroke registry, we identified AIS patients hospitalized within 24 hours of onset with available NFTG results. The primary outcome was a composite of stroke recurrence, myocardial infarction, and all-cause mortality up to one year. Results: This study analyzed 2,176 patients. The prevalence of fasting and non-fasting hypertriglyceridemia was 11.5% and 24.6%, respectively. Multivariate analysis revealed that younger age, diabetes, higher body mass index and initial systolic blood pressure were independently associated with both fasting and non-fasting hypertriglyceridemia (all P < 0.05). Patients with higher quartiles of NFTG were more likely to be male, younger, ever smokers, diabetic, and have family histories of premature coronary heart disease and stroke (all P < 0.05). Similar tendencies were observed for FTG. The composite outcome was not associated with FTG or NFTG quartiles. Conclusion: The fasting and non-fasting hypertriglyceridemia were prevalent in AIS patients and showed similar clinical characteristics and outcomes. High FTG and NFTG levels were not associated with occurrence of subsequent clinical events up to one year.
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