A self-triggered radioligand therapy agent for fluorescence imaging of the treatment response in prostate cancer
DC Field | Value | Language |
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dc.contributor.author | Xu, Hongchuang | - |
dc.contributor.author | Wang, Yanpu | - |
dc.contributor.author | Zhang, Jingming | - |
dc.contributor.author | Duan, Xiaojiang | - |
dc.contributor.author | Zhang, Ting | - |
dc.contributor.author | Cai, Xuekang | - |
dc.contributor.author | Ha, Hyunsoo | - |
dc.contributor.author | Byun, Youngjoo | - |
dc.contributor.author | Fan, Yan | - |
dc.contributor.author | Yang, Zhi | - |
dc.contributor.author | Wang, Yiguang | - |
dc.contributor.author | Liu, Zhaofei | - |
dc.contributor.author | Yang, Xing | - |
dc.date.accessioned | 2022-08-15T01:40:55Z | - |
dc.date.available | 2022-08-15T01:40:55Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1619-7070 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143217 | - |
dc.description.abstract | Purpose Radioligand therapy (RLT) targeting prostate-specific membrane antigen (PSMA) is emerging as an effective treatment option for metastatic castration-resistant prostate cancer (mCRPC). An imaging-based method to quantify early treatment responses can help to understand and optimize RLT. Methods We developed a self-triggered probe 2 targeting the colocalization of PSMA and caspase-3 for fluorescence imaging of RLT-induced apoptosis. Results The probe binds to PSMA potently with a K-i of 4.12 nM, and its fluorescence can be effectively switched on by caspase-3 with a K-m of 67.62 mu M. Cellular and in vivo studies demonstrated its specificity for imaging radiation-induced caspase-3 upregulation in prostate cancer. To identify the detection limit of our method, we showed that probe 2 could achieve 1.79 times fluorescence enhancement in response to Lu-177-RLT in a medium PSMA-expressing 22Rv1 xenograft model. Conclusion Probe 2 can potently bind to PSMA, and the fluorescence signal can be sensitively switched on by caspase-3 both in vitro and in vivo. This method may provide an effective tool to investigate and optimize PSMA-RLT. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | PSMA INHIBITOR | - |
dc.subject | ACID | - |
dc.subject | APOPTOSIS | - |
dc.subject | DIAGNOSIS | - |
dc.subject | CASPASE-3 | - |
dc.subject | DESIGN | - |
dc.title | A self-triggered radioligand therapy agent for fluorescence imaging of the treatment response in prostate cancer | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Byun, Youngjoo | - |
dc.identifier.doi | 10.1007/s00259-022-05743-7 | - |
dc.identifier.scopusid | 2-s2.0-85125544772 | - |
dc.identifier.wosid | 000763377300001 | - |
dc.identifier.bibliographicCitation | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING, v.49, no.8, pp.2693 - 2704 | - |
dc.relation.isPartOf | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.title | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | - |
dc.citation.volume | 49 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 2693 | - |
dc.citation.endPage | 2704 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | PSMA INHIBITOR | - |
dc.subject.keywordPlus | ACID | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | CASPASE-3 | - |
dc.subject.keywordPlus | DESIGN | - |
dc.subject.keywordAuthor | Radioligand therapy | - |
dc.subject.keywordAuthor | Prostate cancer | - |
dc.subject.keywordAuthor | Prostate-specific membrane antigen (PSMA) | - |
dc.subject.keywordAuthor | Self-triggered probe | - |
dc.subject.keywordAuthor | Caspase-3 | - |
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