A prospective multi-centre study of susceptibility map-weighted MRI for the diagnosis of neurodegenerative parkinsonism
DC Field | Value | Language |
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dc.contributor.author | Sung, Young Hee | - |
dc.contributor.author | Kim, Joong-Seok | - |
dc.contributor.author | Yoo, Sang-Won | - |
dc.contributor.author | Shin, Na-Young | - |
dc.contributor.author | Nam, Yoonho | - |
dc.contributor.author | Ahn, Tae-Beom | - |
dc.contributor.author | Yoo, Dallah | - |
dc.contributor.author | Lee, Kyung Mi | - |
dc.contributor.author | Kim, Hyug-Gi | - |
dc.contributor.author | Koh, Seong-Beom | - |
dc.contributor.author | Kim, Jinhee | - |
dc.contributor.author | Kim, Ilsoo | - |
dc.contributor.author | Kwon, Do-Young | - |
dc.contributor.author | Lee, Younghen | - |
dc.contributor.author | Kim, Chulhan | - |
dc.contributor.author | Chung, Sun Ju | - |
dc.contributor.author | Jo, Sungyang | - |
dc.contributor.author | Lee, Seung Hyun | - |
dc.contributor.author | Kim, Sang Joon | - |
dc.contributor.author | Kim, Minjae | - |
dc.contributor.author | Lyoo, Chul Hyoung | - |
dc.contributor.author | Baek, Min Seok | - |
dc.contributor.author | Kang, Suk Yun | - |
dc.contributor.author | Chang, Suk Ki | - |
dc.contributor.author | Jo, Sang-Won | - |
dc.contributor.author | Lee, Seun Ah | - |
dc.contributor.author | Ma, Hyeo-il | - |
dc.contributor.author | Kim, Young Eun | - |
dc.contributor.author | Kim, Eun Soo | - |
dc.contributor.author | Kim, Yun Joong | - |
dc.contributor.author | Kim, Hyun Sook | - |
dc.contributor.author | Woo, Min-Hee | - |
dc.contributor.author | Choi, Hye Jeong | - |
dc.contributor.author | Kim, Eung Yeop | - |
dc.date.accessioned | 2022-08-15T03:40:58Z | - |
dc.date.available | 2022-08-15T03:40:58Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022-05 | - |
dc.identifier.issn | 0938-7994 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143227 | - |
dc.description.abstract | Objectives This study aimed to compare susceptibility map-weighted imaging (SMwI) using various MRI machines (three vendors) with N-3-fluoropropyl-2-beta-carbomethoxy-3-beta-(4-iodophe nyl)nortropane (F-18-FP-CIT) PET in the diagnosis of neurodegenerative parkinsonism in a multi-centre setting. Methods We prospectively recruited 257 subjects, including 157 patients with neurodegenerative parkinsonism, 54 patients with non-neurodegenerative parkinsonism, and 46 healthy subjects from 10 hospitals between November 2019 and October 2020. All participants underwent both SMwI and F-18-FP-CIT PET. SMwI was interpreted by two independent reviewers for the presence or absence of abnormalities in nigrosome 1, and discrepancies were resolved by consensus. F-18-FP-CIT PET was used as the reference standard. Inter-observer agreement was tested using Cohen's kappa coefficient. McNemar's test was used to test the agreement between the interpretations of SMwI and F-18-FP-CIT PET per participant and substantia nigra (SN). Results The inter-observer agreement was 0.924 and 0.942 per SN and participant, respectively. The diagnostic sensitivity of SMwI was 97.9% and 99.4% per SN and participant, respectively; its specificity was 95.9% and 95.2%, respectively, and its accuracy was 97.1% and 97.7%, respectively. There was no significant difference between the results of SMwI and F-18-FP-CIT PET (p > 0.05, for both SN and participant). Conclusions This study demonstrated that the high diagnostic performance of SMwI was maintained in a multi-centre setting with various MRI scanners, suggesting the generalisability of SMwI for determining nigrostriatal degeneration in patients with parkinsonism. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | DORSOLATERAL NIGRAL HYPERINTENSITY | - |
dc.subject | SUBSTANTIA-NIGRA | - |
dc.subject | NIGROSOME 1 | - |
dc.subject | CLINICAL-DIAGNOSIS | - |
dc.subject | ESSENTIAL TREMOR | - |
dc.subject | ACCURACY | - |
dc.subject | DISEASE | - |
dc.subject | CRITERIA | - |
dc.subject | 3T | - |
dc.title | A prospective multi-centre study of susceptibility map-weighted MRI for the diagnosis of neurodegenerative parkinsonism | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kwon, Do-Young | - |
dc.identifier.doi | 10.1007/s00330-021-08454-z | - |
dc.identifier.scopusid | 2-s2.0-85123306989 | - |
dc.identifier.wosid | 000745408500005 | - |
dc.identifier.bibliographicCitation | EUROPEAN RADIOLOGY, v.32, no.5, pp.3597 - 3608 | - |
dc.relation.isPartOf | EUROPEAN RADIOLOGY | - |
dc.citation.title | EUROPEAN RADIOLOGY | - |
dc.citation.volume | 32 | - |
dc.citation.number | 5 | - |
dc.citation.startPage | 3597 | - |
dc.citation.endPage | 3608 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.relation.journalWebOfScienceCategory | Radiology, Nuclear Medicine & Medical Imaging | - |
dc.subject.keywordPlus | DORSOLATERAL NIGRAL HYPERINTENSITY | - |
dc.subject.keywordPlus | SUBSTANTIA-NIGRA | - |
dc.subject.keywordPlus | NIGROSOME 1 | - |
dc.subject.keywordPlus | CLINICAL-DIAGNOSIS | - |
dc.subject.keywordPlus | ESSENTIAL TREMOR | - |
dc.subject.keywordPlus | ACCURACY | - |
dc.subject.keywordPlus | DISEASE | - |
dc.subject.keywordPlus | CRITERIA | - |
dc.subject.keywordPlus | 3T | - |
dc.subject.keywordAuthor | Parkinson disease | - |
dc.subject.keywordAuthor | Substantia nigra | - |
dc.subject.keywordAuthor | Magnetic resonance imaging | - |
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