Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies
DC Field | Value | Language |
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dc.contributor.author | Na, Yoonhye | - |
dc.contributor.author | Jung, JeYoung | - |
dc.contributor.author | Tench, Christopher R. | - |
dc.contributor.author | Auer, Dorothee P. | - |
dc.contributor.author | Pyun, Sung-Bom | - |
dc.date.accessioned | 2022-08-15T12:40:19Z | - |
dc.date.available | 2022-08-15T12:40:19Z | - |
dc.date.created | 2022-08-12 | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 2213-1582 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143269 | - |
dc.description.abstract | Background: Aphasia is one of the most common causes of post-stroke disabilities. As the symptoms and impact of post-stroke aphasia are heterogeneous, it is important to understand how topographical lesion heterogeneity in patients with aphasia is associated with different domains of language impairments. Here, we aim to provide a comprehensive overview of neuroanatomical basis in post-stroke aphasia through coordinate based meta analysis of voxel-based lesion-symptom mapping studies.Methods: We performed a meta-analysis of lesion-symptom mapping studies in post-stroke aphasia. We obtained coordinate-based structural neuroimaging data for 2,007 individuals with aphasia from 25 studies that met predefined inclusion criteria.Results: Overall, our results revealed that the distinctive patterns of lesions in aphasia are associated with different language functions and tasks. Damage to the insular-motor areas impaired speech with preserved comprehension and a similar pattern was observed when the lesion covered the insular-motor and inferior parietal lobule. Lesions in the frontal area severely impaired speaking with relatively good comprehension. The repetition-selective deficits only arise from lesions involving the posterior superior temporal gyrus. Damage in the anterior-to-posterior temporal cortex was associated with semantic deficits.Conclusion: The association patterns of lesion topography and specific language deficits provide key insights into the specific underlying language pathways. Our meta-analysis results strongly support the dual pathway model of language processing, capturing the link between the different symptom complexes of aphasias and the different underlying location of damage. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | ANTERIOR TEMPORAL INVOLVEMENT | - |
dc.subject | SEMANTIC IMPAIRMENT | - |
dc.subject | SPEECH PRODUCTION | - |
dc.subject | FUNCTIONAL NEUROANATOMY | - |
dc.subject | PHONOLOGICAL RETRIEVAL | - |
dc.subject | ARCUATE FASCICULUS | - |
dc.subject | DORSAL | - |
dc.subject | DEFICITS | - |
dc.subject | STROKE | - |
dc.subject | WORD | - |
dc.title | Language systems from lesion-symptom mapping in aphasia: A meta-analysis of voxel-based lesion mapping studies | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Pyun, Sung-Bom | - |
dc.identifier.doi | 10.1016/j.nicl.2022.103038 | - |
dc.identifier.scopusid | 2-s2.0-85130234508 | - |
dc.identifier.wosid | 000806595300009 | - |
dc.identifier.bibliographicCitation | NEUROIMAGE-CLINICAL, v.35 | - |
dc.relation.isPartOf | NEUROIMAGE-CLINICAL | - |
dc.citation.title | NEUROIMAGE-CLINICAL | - |
dc.citation.volume | 35 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Neuroimaging | - |
dc.subject.keywordPlus | ANTERIOR TEMPORAL INVOLVEMENT | - |
dc.subject.keywordPlus | SEMANTIC IMPAIRMENT | - |
dc.subject.keywordPlus | SPEECH PRODUCTION | - |
dc.subject.keywordPlus | FUNCTIONAL NEUROANATOMY | - |
dc.subject.keywordPlus | PHONOLOGICAL RETRIEVAL | - |
dc.subject.keywordPlus | ARCUATE FASCICULUS | - |
dc.subject.keywordPlus | DORSAL | - |
dc.subject.keywordPlus | DEFICITS | - |
dc.subject.keywordPlus | STROKE | - |
dc.subject.keywordPlus | WORD | - |
dc.subject.keywordAuthor | Stroke | - |
dc.subject.keywordAuthor | Aphasia | - |
dc.subject.keywordAuthor | Neuroimaging | - |
dc.subject.keywordAuthor | Language | - |
dc.subject.keywordAuthor | Brain mapping | - |
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