Melanoma Detection by AFM Indentation of Histological Specimens
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jeon, Byoungjun | - |
dc.contributor.author | Jung, Hyo Gi | - |
dc.contributor.author | Lee, Sang Won | - |
dc.contributor.author | Lee, Gyudo | - |
dc.contributor.author | Shim, Jung Hee | - |
dc.contributor.author | Kim, Mi Ok | - |
dc.contributor.author | Kim, Byung Jun | - |
dc.contributor.author | Kim, Sang-Hyon | - |
dc.contributor.author | Lee, Hyungbeen | - |
dc.contributor.author | Lee, Sang Woo | - |
dc.contributor.author | Yoon, Dae Sung | - |
dc.contributor.author | Jo, Seong Jin | - |
dc.contributor.author | Choi, Tae Hyun | - |
dc.contributor.author | Lee, Wonseok | - |
dc.date.accessioned | 2022-08-25T16:40:20Z | - |
dc.date.available | 2022-08-25T16:40:20Z | - |
dc.date.created | 2022-08-25 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 2075-4418 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143365 | - |
dc.description.abstract | Melanoma is visible unlike other types of cancer, but it is still challenging to diagnose correctly because of the difficulty in distinguishing between benign nevus and melanoma. We conducted a robust investigation of melanoma, identifying considerable differences in local elastic properties between nevus and melanoma tissues by using atomic force microscopy (AFM) indentation of histological specimens. Specifically, the histograms of the elastic modulus of melanoma displayed multimodal Gaussian distributions, exhibiting heterogeneous mechanical properties, in contrast with the unimodal distributions of elastic modulus in the benign nevus. We identified this notable signature was consistent regardless of blotch incidence by sex, age, anatomical site (e.g., thigh, calf, arm, eyelid, and cheek), or cancer stage (I, IV, and V). In addition, we found that the non-linearity of the force-distance curves for melanoma is increased compared to benign nevus. We believe that AFM indentation of histological specimens may technically complement conventional histopathological analysis for earlier and more precise melanoma detection. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | ELECTRICAL-IMPEDANCE SPECTROSCOPY | - |
dc.subject | NANOMECHANICAL SIGNATURE | - |
dc.subject | EXTRACELLULAR-MATRIX | - |
dc.subject | ELASTIC PROPERTIES | - |
dc.subject | HUMAN SKIN | - |
dc.subject | TISSUES | - |
dc.subject | NANOINDENTATION | - |
dc.subject | ULTRASOUND | - |
dc.subject | MICROSCOPY | - |
dc.subject | DIAGNOSIS | - |
dc.title | Melanoma Detection by AFM Indentation of Histological Specimens | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Gyudo | - |
dc.identifier.doi | 10.3390/diagnostics12071736 | - |
dc.identifier.scopusid | 2-s2.0-85137333710 | - |
dc.identifier.wosid | 000833374600001 | - |
dc.identifier.bibliographicCitation | DIAGNOSTICS, v.12, no.7 | - |
dc.relation.isPartOf | DIAGNOSTICS | - |
dc.citation.title | DIAGNOSTICS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | DIAGNOSIS | - |
dc.subject.keywordPlus | ELASTIC PROPERTIES | - |
dc.subject.keywordPlus | ELECTRICAL-IMPEDANCE SPECTROSCOPY | - |
dc.subject.keywordPlus | EXTRACELLULAR-MATRIX | - |
dc.subject.keywordPlus | HUMAN SKIN | - |
dc.subject.keywordPlus | MICROSCOPY | - |
dc.subject.keywordPlus | NANOINDENTATION | - |
dc.subject.keywordPlus | NANOMECHANICAL SIGNATURE | - |
dc.subject.keywordPlus | TISSUES | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordAuthor | atomic force microscopy | - |
dc.subject.keywordAuthor | benign nevus | - |
dc.subject.keywordAuthor | malignant melanoma | - |
dc.subject.keywordAuthor | mechanical characterization | - |
dc.subject.keywordAuthor | nanoindentation | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.