The Clinical Impact of beta-Blocker Therapy on Patients With Chronic Coronary Artery Disease After Percutaneous Coronary Intervention
DC Field | Value | Language |
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dc.contributor.author | Park, Jiesuck | - |
dc.contributor.author | Han, Jung-Kyu | - |
dc.contributor.author | Kang, Jeehoon | - |
dc.contributor.author | Chae, In-Ho | - |
dc.contributor.author | Lee, Sung Yun | - |
dc.contributor.author | Choi, Young Jin | - |
dc.contributor.author | Rhew, Jay Young | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Shin, Eun-Seok | - |
dc.contributor.author | Woo, Seong-Ill | - |
dc.contributor.author | Lee, Han Cheol | - |
dc.contributor.author | Chun, Kook-Jin | - |
dc.contributor.author | Kim, Dooil | - |
dc.contributor.author | Jeong, Jin-Ok | - |
dc.contributor.author | Bae, Jang-Whan | - |
dc.contributor.author | Yang, Han-Mo | - |
dc.contributor.author | Park, Kyung Woo | - |
dc.contributor.author | Kang, Hyun-Jae | - |
dc.contributor.author | Koo, Bon-Kwon | - |
dc.contributor.author | Kim, Hyo-Soo | - |
dc.date.accessioned | 2022-08-25T19:40:45Z | - |
dc.date.available | 2022-08-25T19:40:45Z | - |
dc.date.created | 2022-08-25 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143382 | - |
dc.description.abstract | Background and Objectives: The outcome benefits of n-blockers in chronic coronary artery disease (CAD) have not been fully assessed. We evaluated the prognostic impact of n-blockers on patients with chronic CAD after percutaneous coronary intervention (PCI). Methods: A total of 3,075 patients with chronic CAD were included from the Grand Drug -Eluting Stent registry. We analyzed n-blocker prescriptions, including doses and types, in each patient at 3-month intervals from discharge. After propensity score matching, 1,170 pairs of patients (B-blockers vs. no B-blockers) were derived. Primary outcome was defined as a composite endpoint of all-cause death and myocardial infarction (MI). We further analyzed the outcome benefits of different doses (low-, medium-, and high-dose) and types (conventional or vasodilating) of B-blockers. Results: During a median (interquartile range) follow-up of 3.1 (3.0-3.1) years, 134 (5.7%) patients experienced primary outcome. Overall, B-blockers demonstrated no significant benefit in primary outcome (hazard ratio [HR], 0.88; 95% confidence interval [CI], 0.63-1.24), all-cause death (HR, 0.87; 95% CI, 0.60-1.25), and MI (HR, 1.25; 95% CI, 0.49-3.15). In subgroup analysis, B-blockers were associated with a lower risk of all-cause death in patients with previous MI and/ or revascularization (HR, 0.38; 95% CI, 0.14-0.99) (p for interaction=0.045). No significant associations were found for the clinical outcomes with different doses and types of B-blockers. Conclusions: Overall, B-blocker therapy was not associated with better clinical outcomes in patients with chronic CAD undergoing PCI. Limited mortality benefit of B-blockers may exist for patients with previous MI and/or revascularization. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC CARDIOLOGY | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | STABLE ANGINA | - |
dc.subject | DOUBLE-BLIND | - |
dc.subject | OUTCOMES | - |
dc.subject | EVENTS | - |
dc.subject | METAANALYSIS | - |
dc.subject | PROPRANOLOL | - |
dc.subject | CARVEDILOL | - |
dc.subject | SURVIVAL | - |
dc.title | The Clinical Impact of beta-Blocker Therapy on Patients With Chronic Coronary Artery Disease After Percutaneous Coronary Intervention | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.identifier.doi | 10.4070/kcj.2021.0395 | - |
dc.identifier.scopusid | 2-s2.0-85130206627 | - |
dc.identifier.wosid | 000826320000007 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, v.52, no.7, pp.544 - 555 | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.citation.title | KOREAN CIRCULATION JOURNAL | - |
dc.citation.volume | 52 | - |
dc.citation.number | 7 | - |
dc.citation.startPage | 544 | - |
dc.citation.endPage | 555 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002855249 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | CARVEDILOL | - |
dc.subject.keywordPlus | DOUBLE-BLIND | - |
dc.subject.keywordPlus | EVENTS | - |
dc.subject.keywordPlus | METAANALYSIS | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | OUTCOMES | - |
dc.subject.keywordPlus | PROPRANOLOL | - |
dc.subject.keywordPlus | STABLE ANGINA | - |
dc.subject.keywordPlus | SURVIVAL | - |
dc.subject.keywordAuthor | Adrenergic beta-antagonists | - |
dc.subject.keywordAuthor | Angina | - |
dc.subject.keywordAuthor | Percutaneous coronary intervention | - |
dc.subject.keywordAuthor | stable | - |
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