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A Multivalent Vaccine Based on Ferritin Nanocage Elicits Potent Protective Immune Responses against SARS-CoV-2 Mutationsopen access

Authors
Kim, Seong A.Kim, SeohyunKim, Gi BeomGoo, JiyoungKim, NayeonLee, YeramNam, Gi-HoonLim, SeunghoKim, TaeerkChang, Ki HwanLee, Tae GyuKim, In-SanLee, Eun Jung
Issue Date
6월-2022
Publisher
MDPI
Keywords
protein nanocage; ferritin; COVID-19; SARS-CoV-2; variants; multivalent vaccine
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.11
Indexed
SCIE
SCOPUS
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume
23
Number
11
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/143410
DOI
10.3390/ijms23116123
ISSN
1661-6596
Abstract
The SARS-CoV-2 pandemic has created a global public crisis and heavily affected personal lives, healthcare systems, and global economies. Virus variants are continuously emerging, and, thus, the pandemic has been ongoing for over two years. Vaccines were rapidly developed based on the original SARS-CoV-2 (Wuhan-Hu-1) to build immunity against the coronavirus disease. However, they had a very low effect on the virus' variants due to their low cross-reactivity. In this study, a multivalent SARS-CoV-2 vaccine was developed using ferritin nanocages, which display the spike protein from the Wuhan-Hu-1, B.1.351, or B.1.429 SARS-CoV-2 on their surfaces. We show that the mixture of three SARS-CoV-2 spike-protein-displaying nanocages elicits CD4(+) and CD8(+) T cells and B-cell immunity successfully in vivo. Furthermore, they generate a more consistent antibody response against the B.1.351 and B.1.429 variants than a monovalent vaccine. This leads us to believe that the proposed ferritin-nanocage-based multivalent vaccine platform will provide strong protection against emerging SARS-CoV-2 variants of concern (VOCs).
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