Is the Alzheimer's Disease Assessment Scale-Cognitive Subscale Useful in Screening for Mild Cognitive Impairment and Alzheimer's Disease? A Systematic Review
DC Field | Value | Language |
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dc.contributor.author | Park, Seong-Hi | - |
dc.contributor.author | Han, Kuem Sun | - |
dc.date.accessioned | 2022-08-27T10:40:42Z | - |
dc.date.available | 2022-08-27T10:40:42Z | - |
dc.date.created | 2022-08-25 | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1567-2050 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143596 | - |
dc.description.abstract | Background: Mild cognitive impairment (MCI) and Alzheimer's disease (AD) are screened to distinguish whether the cognitive decline in older adults is attributed to pathological causes rather than normal aging. Objective: The purpose of this review was to analyze the diagnostic performance of the Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog) in screening for MCI and AD. Methods: Electronic searches were performed on MEDLINE, EMBASE, CINAHL, and PsycArticles databases using the following keywords: dementia and ADAS-Cog. The Quality Assessment of Diagnostic Accuracy Studies-2 was used to check the risk of bias in the diagnostic studies. Results: We reviewed 14 studies, including 3,875 patients who met the selection criteria. In 2,624 MCI patients from nine studies, the pooled sensitivity of ADAS-Cog was 0.80 (95% confidence interval [CI], 0.68-0.88), the pooled specificity was 0.84 (95% CI, 0.75-0.90), and the area under the curve of summary receiver-operating characteristic curves (SROC AUC) was 0.89 (SE = 0.03). In 2,517 AD patients from 10 studies, the pooled sensitivity and pooled specificity were 0.91 (95% CI, 0.86-0.95) and 0.93 (95% CI, 0.88-0.95), respectively, and the sROC AUC was 0.97 (SE = 0.01). Although sub-analyzed according to age and years of education, there was no significant difference in the predictive validity of the ADAS-Cog. Conclusion: The ADAS-Cog has high predictive validity as a screening tool in both MCI and AD and has better diagnostic performance in patients with AD. When early screening for AD is desired, ADAS-Cog is a first-stage screening tool that can be initially employed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BENTHAM SCIENCE PUBL LTD | - |
dc.subject | ADAS-COG | - |
dc.subject | DEMENTIA | - |
dc.subject | VERSION | - |
dc.subject | VALIDITY | - |
dc.subject | AGE | - |
dc.title | Is the Alzheimer's Disease Assessment Scale-Cognitive Subscale Useful in Screening for Mild Cognitive Impairment and Alzheimer's Disease? A Systematic Review | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Han, Kuem Sun | - |
dc.identifier.doi | 10.2174/1567205019666220404104854 | - |
dc.identifier.scopusid | 2-s2.0-85132920952 | - |
dc.identifier.wosid | 000836179200003 | - |
dc.identifier.bibliographicCitation | CURRENT ALZHEIMER RESEARCH, v.19, no.3, pp.202 - 211 | - |
dc.relation.isPartOf | CURRENT ALZHEIMER RESEARCH | - |
dc.citation.title | CURRENT ALZHEIMER RESEARCH | - |
dc.citation.volume | 19 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 202 | - |
dc.citation.endPage | 211 | - |
dc.type.rims | ART | - |
dc.type.docType | Review | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalWebOfScienceCategory | Clinical Neurology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.subject.keywordPlus | ADAS-COG | - |
dc.subject.keywordPlus | DEMENTIA | - |
dc.subject.keywordPlus | VERSION | - |
dc.subject.keywordPlus | VALIDITY | - |
dc.subject.keywordPlus | AGE | - |
dc.subject.keywordAuthor | Alzheimer&apos | - |
dc.subject.keywordAuthor | s disease | - |
dc.subject.keywordAuthor | cognitive dysfunction | - |
dc.subject.keywordAuthor | older adults | - |
dc.subject.keywordAuthor | neuropsychological tests | - |
dc.subject.keywordAuthor | sensitivity | - |
dc.subject.keywordAuthor | specificity | - |
dc.subject.keywordAuthor | systematic review | - |
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