A Shear-Thinning Biomaterial-Mediated Immune Checkpoint Blockade
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Wu, Qingzhi | - |
dc.contributor.author | Qu, Moyuan | - |
dc.contributor.author | Kim, Han-Jun | - |
dc.contributor.author | Zhou, Xingwu | - |
dc.contributor.author | Jiang, Xing | - |
dc.contributor.author | Chen, Yi | - |
dc.contributor.author | Zhu, Jixiang | - |
dc.contributor.author | Ren, Li | - |
dc.contributor.author | Wolter, Tyler | - |
dc.contributor.author | Kang, Heemin | - |
dc.contributor.author | Xu, Chun | - |
dc.contributor.author | Gu, Zhen | - |
dc.contributor.author | Sun, Wujin | - |
dc.contributor.author | Khademhosseini, Ali | - |
dc.date.accessioned | 2022-09-23T19:41:01Z | - |
dc.date.available | 2022-09-23T19:41:01Z | - |
dc.date.created | 2022-09-23 | - |
dc.date.issued | 2022-08-10 | - |
dc.identifier.issn | 1944-8244 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143785 | - |
dc.description.abstract | Systemic administration of immune checkpoint blockade agents can activate the anticancer activity of immune cells; however, the response varies from patient to patient and presents potential off-target toxicities. Local administration of immune checkpoint inhibitors (ICIs) can maximize therapeutic efficacies while reducing side effects. This study demonstrates a minimally invasive strategy to locally deliver anti-programmed cell death protein 1 (anti-PD 1) with shear-thinning biomaterials (STBs). ICI can be injected into tumors when loaded in STBs (STB-ICI) composed of gelatin and silicate nanoplatelets (Laponite). The release of ICI from STB was mainly affected by the Laponite percentage in STBs and pH of the local microenvironment. Low Laponite content and acidic pH can induce ICI release. In a murine melanoma model, the injection of STB-ICI significantly reduced tumor growth and increased CD8(+) T cell level in peripheral blood. STB-ICI also induced increased levels of tumor infiltrating CD4(+) helper T cells, CD8(+) cytotoxic T cells, and tumor death. The STB-based minimally invasive strategy provides a simple and efficient approach to deliver ICIs locally. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.subject | CANCER-IMMUNOTHERAPY | - |
dc.subject | HYDROGEL | - |
dc.subject | TOXICITIES | - |
dc.title | A Shear-Thinning Biomaterial-Mediated Immune Checkpoint Blockade | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kang, Heemin | - |
dc.identifier.doi | 10.1021/acsami.2c06137 | - |
dc.identifier.scopusid | 2-s2.0-85135769067 | - |
dc.identifier.wosid | 000835541800001 | - |
dc.identifier.bibliographicCitation | ACS APPLIED MATERIALS & INTERFACES, v.14, no.31, pp.35309 - 35318 | - |
dc.relation.isPartOf | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.title | ACS APPLIED MATERIALS & INTERFACES | - |
dc.citation.volume | 14 | - |
dc.citation.number | 31 | - |
dc.citation.startPage | 35309 | - |
dc.citation.endPage | 35318 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Nanoscience & Nanotechnology | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Multidisciplinary | - |
dc.subject.keywordPlus | CANCER-IMMUNOTHERAPY | - |
dc.subject.keywordPlus | HYDROGEL | - |
dc.subject.keywordPlus | TOXICITIES | - |
dc.subject.keywordAuthor | cancer immunotherapy | - |
dc.subject.keywordAuthor | drug delivery | - |
dc.subject.keywordAuthor | immune checkpoint blockade | - |
dc.subject.keywordAuthor | shear-thinning biomaterials | - |
dc.subject.keywordAuthor | sustained release | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.