Kinetics of neutralizing antibodies against SARS-CoV-2 infection according to sex, age, and disease severity
DC Field | Value | Language |
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dc.contributor.author | Kim, Yoonjung | - |
dc.contributor.author | Bae, Joon-Yong | - |
dc.contributor.author | Kwon, Kitae | - |
dc.contributor.author | Chang, Hyun-Ha | - |
dc.contributor.author | Lee, Won Kee | - |
dc.contributor.author | Park, Heedo | - |
dc.contributor.author | Kim, Jeonghun | - |
dc.contributor.author | Choi, Isaac | - |
dc.contributor.author | Park, Man-Seong | - |
dc.contributor.author | Kim, Shin-Woo | - |
dc.date.accessioned | 2022-09-23T21:40:30Z | - |
dc.date.available | 2022-09-23T21:40:30Z | - |
dc.date.created | 2022-09-23 | - |
dc.date.issued | 2022-08-05 | - |
dc.identifier.issn | 2045-2322 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143795 | - |
dc.description.abstract | Knowledge of the factors affecting the difference in kinetics and longevity of the neutralizing antibody (nAb) response to SARS-CoV-2 is necessary to properly prioritize vaccination. In the present study, from March to December 2020, of the 143 patients who recovered from COVID-19, 87 underwent study visits scheduled every 3 months. Patient demographics and blood samples were collected followed by a plaque reduction neutralization test to analyze nAb titers. A linear mixed model was used to compare the effects of sex, age, and disease severity over time. Results demonstrated a gradual reduction in nAb titers over time with a significant decrease from 6 to 9 months post-COVID-19 infection (p < 0.001). In time-to-sex, age, and disease severity comparisons, reduction in nAb titers over time was unaffected by sex (p = 0.167), age (p = 0.188), or disease severity (p = 0.081). Additionally, the nAb titer was 1.46 times significantly higher in those aged >= 50 years than in those aged < 50 years (p = 0.036) irrespective of time Moreover, the nAb titer was 2.41 times higher in the moderate or above than that in the below moderate disease severity group (p < 0.001). However, no significant differences were observed in terms of sex (p = 0.300). Given the reduction in nAbs over time, maintaining protective neutralizing antibodies regardless of sex, age, or disease severity is needed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | NATURE PORTFOLIO | - |
dc.subject | RATES | - |
dc.title | Kinetics of neutralizing antibodies against SARS-CoV-2 infection according to sex, age, and disease severity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Man-Seong | - |
dc.identifier.doi | 10.1038/s41598-022-17605-1 | - |
dc.identifier.scopusid | 2-s2.0-85135598319 | - |
dc.identifier.wosid | 000836707300045 | - |
dc.identifier.bibliographicCitation | SCIENTIFIC REPORTS, v.12, no.1 | - |
dc.relation.isPartOf | SCIENTIFIC REPORTS | - |
dc.citation.title | SCIENTIFIC REPORTS | - |
dc.citation.volume | 12 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | RATES | - |
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