Filling gaps between exposure modeling and the analysis of urinary biomarkers using personal air monitoring: An intervention study of permethrin used in home insecticide spray
- Authors
- Park, Seon-Kyung; Lee, Heon-Jun; Song, Eugene; Jung, Yerin; Yoo, Hyun Jung; Oh, Jeong-Eun; Shin, Hyeong-Moo; Kwon, Jung-Hwan
- Issue Date
- Aug-2022
- Publisher
- WILEY
- Keywords
- air monitoring; exposure modeling; home insecticide; indoor air modeling; intervention study; permethrin
- Citation
- INDOOR AIR, v.32, no.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- INDOOR AIR
- Volume
- 32
- Number
- 8
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/143821
- DOI
- 10.1111/ina.13090
- ISSN
- 0905-6947
- Abstract
- Permethrin is one of the most widely used active ingredients in spray-type home insecticides. However, indoor permethrin exposure resulting from the use of home insecticides is not well-characterized, as measured permethrin concentrations in indoor environmental and biological media with a known application rate are scarce. We conducted an intervention study with four participants for seven days. We conducted personal air monitoring and collected 24-h urine samples in which we quantified time-weighted average (TWA) permethrin concentrations in indoor air (C-air) and urinary concentrations of two permethrin metabolites, 3-phenoxybenzoic acid (3-PBA) and cis/trans-3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropane carboxylic acid (cis/trans-DCCA). We also estimated (1) TWA C-air using a simple indoor air model and (2) urinary excreted (UE) mass using a simple excretion model with both estimated and measured TWA C-air. Measurements of TWA C-air from personal air monitoring were lower than those estimated from the indoor model by a factor of 2.9 to 49.4. The ratio of estimated to measured UE mass ranged 3.5-18.2 when using estimated TWA C-air and 1.1-2.9 when using measured TWA C-air. Smaller ratios in estimating internal permethrin exposure from personal air monitoring suggest that personal air monitoring could reduce uncertainties in permethrin exposure assessment resulting from the use of spray-type insecticides.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - College of Life Sciences and Biotechnology > Division of Environmental Science and Ecological Engineering > 1. Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.