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Protective effects of pentoxifylline on T-cell viability under inflammatory conditions

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dc.contributor.authorPark, Sung-Joon-
dc.contributor.authorChoi, Sung-Hyuk-
dc.contributor.authorCho, Young-Duck-
dc.contributor.authorKim, Jung-Youn-
dc.contributor.authorCho, Han-Jin-
dc.contributor.authorKim, Kyung-Hwan-
dc.contributor.authorKim, Won-Young-
dc.date.accessioned2022-09-24T04:40:49Z-
dc.date.available2022-09-24T04:40:49Z-
dc.date.created2022-09-23-
dc.date.issued2022-08-
dc.identifier.issn1721-727X-
dc.identifier.urihttps://scholar.korea.ac.kr/handle/2021.sw.korea/143832-
dc.description.abstractIntroduction: Pentoxifylline (PTX) reduces the levels of pro-inflammatory cytokines; however, its effects on immune system is not well understood. The aim of this study was to investigate the effect of PTX on T cells under inflammatory conditions in co-culture with THP-1-derived macrophages. Methods: Toll-like receptor 4 (TLR4) and macrophage migration inhibitory factor (MIF) levels were measured after addition of PTX to lipopolysaccharide (LPS)-stimulated differentiated THP-1 cells. T cell viability and MIF levels were measured after PTX was added to prostaglandin E-2 (PGE(2))-stimulated Jurkat T-cell leukemia line. Co-culture was conducted to determine the effect of LPS-stimulated differentiated THP-1 cells that are affected by PTX on Jurkat cells. To prevent the direct effects of LPS and PTX on Jurkat cells, LPS and PTX were washed from THP-1 cells before co-culture. T cell viability and interleukin-2 (IL-2) levels were determined in Jurkat cells. Results: Increase in the MIF concentration and TLR4 expression level in differentiated THP-1 cells stimulated with LPS were reversed after PTX addition. However, PTX did not improve T cell viability in PGE(2)-stimulated Jurkat cells. Co-culturing Jurkat cell and LPS-stimulated differentiated THP-1 cells resulted in a decreased viability of T cells. The addition of PTX restored T cell viability to normal control levels and IL-2 expression level in Jurkat cells. Conclusion: LPS-stimulated THP-1-derived macrophages reduced the T cell viability under inflammation. However, PTX restored T cells viability and IL-2 back to normal levels. Therefore, the immunomodulatory action of PTX may be mediated by macrophage-T cell interactions.-
dc.languageEnglish-
dc.language.isoen-
dc.publisherSAGE PUBLICATIONS INC-
dc.subjectMIGRATION INHIBITORY FACTOR-
dc.subjectDENDRITIC CELLS-
dc.subjectSEVERE SEPSIS-
dc.subjectINTERLEUKIN-2-
dc.subjectINCREASES-
dc.subjectMIF-
dc.titleProtective effects of pentoxifylline on T-cell viability under inflammatory conditions-
dc.typeArticle-
dc.contributor.affiliatedAuthorChoi, Sung-Hyuk-
dc.identifier.doi10.1177/1721727X221120753-
dc.identifier.scopusid2-s2.0-85136973217-
dc.identifier.wosid000846840200001-
dc.identifier.bibliographicCitationEUROPEAN JOURNAL OF INFLAMMATION, v.20-
dc.relation.isPartOfEUROPEAN JOURNAL OF INFLAMMATION-
dc.citation.titleEUROPEAN JOURNAL OF INFLAMMATION-
dc.citation.volume20-
dc.type.rimsART-
dc.type.docTypeArticle-
dc.description.journalClass1-
dc.description.isOpenAccessY-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaImmunology-
dc.relation.journalWebOfScienceCategoryImmunology-
dc.subject.keywordPlusDENDRITIC CELLS-
dc.subject.keywordPlusINCREASES-
dc.subject.keywordPlusINTERLEUKIN-2-
dc.subject.keywordPlusMIF-
dc.subject.keywordPlusMIGRATION INHIBITORY FACTOR-
dc.subject.keywordPlusSEVERE SEPSIS-
dc.subject.keywordAuthorTrauma-
dc.subject.keywordAuthorinterleukin 2-
dc.subject.keywordAuthorlymphocyte-
dc.subject.keywordAuthorpentoxifylline-
dc.subject.keywordAuthortoll-like receptor-
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