Upregulation of VSIG4 in Type 2 Diabetic Kidney Disease
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Han, Sang Youb | - |
dc.contributor.author | Ghee, Jung Yeon | - |
dc.contributor.author | Cha, Jin Joo | - |
dc.contributor.author | Kang, Young Sun | - |
dc.contributor.author | Hur, Dae Young | - |
dc.contributor.author | Kim, Han Seong | - |
dc.contributor.author | Cha, Dae Ryong | - |
dc.date.accessioned | 2022-09-24T11:40:20Z | - |
dc.date.available | 2022-09-24T11:40:20Z | - |
dc.date.created | 2022-09-23 | - |
dc.date.issued | 2022-07 | - |
dc.identifier.issn | 0024-3019 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143878 | - |
dc.description.abstract | Fibrosis is the final common finding in patients with advanced diabetic kidney disease. V-set Ig domain containing 4 (VSIG4) is related to fibrosis in several diseases. It also contributes to fibrosis under high-glucose conditions in renal tubule cells. To determine the role of VSIG4 in type 2 diabetes, we examined VSIG4 expression in a type 2 diabetic animal model and podocyte. Urinary excretion of albumin and VSIG4 was significantly higher in db/db mice than in the control group. Urine VSIGs levels for 6 h were about three-fold higher in db/db mice than in db/m mice at 20 weeks of age: 55.2 +/- 37.8 vs. 153.1 +/- 74.3 ng, p = 0.04. Furthermore, urinary VSIG4 levels were significantly correlated with urinary albumin levels (r = 0.77, p < 0.01). Intrarenal VSIG4 mRNA expression was significantly higher in db/db mice than in control mice (1.00 +/- 0.35 vs. 1.69 +/- 0.77, p = 0.04). Further, VSIG4 expression was almost twice as high in db/db mice at 20 weeks of age. Intrarenal VSIG immunoreactivity in db/db mice was also significantly higher than that in control mice. In cultured podocytes, both high glucose and angiotensin II significantly upregulated the expression of VSIG4 mRNA and protein. In conclusion, VSIG4 was upregulated in an animal model of type 2 diabetes and was related to albuminuria and pro-fibrotic markers. Considering these relationships, VSIG4 may be an important mediator of diabetic nephropathy progression. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | EXPRESSION | - |
dc.subject | CELL | - |
dc.subject | PROTEIN | - |
dc.title | Upregulation of VSIG4 in Type 2 Diabetic Kidney Disease | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cha, Dae Ryong | - |
dc.identifier.doi | 10.3390/life12071031 | - |
dc.identifier.scopusid | 2-s2.0-85137238767 | - |
dc.identifier.wosid | 000833080600001 | - |
dc.identifier.bibliographicCitation | LIFE-BASEL, v.12, no.7 | - |
dc.relation.isPartOf | LIFE-BASEL | - |
dc.citation.title | LIFE-BASEL | - |
dc.citation.volume | 12 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Life Sciences & Biomedicine - Other Topics | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Biology | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | CELL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordAuthor | VSIG4 | - |
dc.subject.keywordAuthor | diabetes | - |
dc.subject.keywordAuthor | fibrosis | - |
dc.subject.keywordAuthor | kidney | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.