Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25
DC Field | Value | Language |
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dc.contributor.author | Kim, D. | - |
dc.contributor.author | Kim, M. | - |
dc.contributor.author | Kim, T.W. | - |
dc.contributor.author | Choe, Y.-H. | - |
dc.contributor.author | Noh, H.S. | - |
dc.contributor.author | Jeon, H.M. | - |
dc.contributor.author | Kim, H. | - |
dc.contributor.author | Lee, Y. | - |
dc.contributor.author | Hur, G. | - |
dc.contributor.author | Lee, K.-M. | - |
dc.contributor.author | Shin, K. | - |
dc.contributor.author | Lee, S.-I. | - |
dc.contributor.author | Lee, S.-H. | - |
dc.date.accessioned | 2022-09-25T06:40:54Z | - |
dc.date.available | 2022-09-25T06:40:54Z | - |
dc.date.created | 2022-09-23 | - |
dc.date.issued | 2022-03 | - |
dc.identifier.issn | 0022-1007 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/143976 | - |
dc.description.abstract | Lymph node fibroblastic reticular cells (LN-FRCs) provide functional structure to LNs and play important roles in interactions between T cells and antigen-presenting cells. However, the direct impact of LN-FRCs on naive CD4+ T cell differentiation has not been explored. Here, we show that T cell zone FRCs of LNs (LN-TRCs) express CD25, the α chain of the IL-2 receptor heterotrimer. Moreover, LN-TRCs trans-present IL-2 to naive CD4+ T cells through CD25, thereby facilitating early IL-2–mediated signaling. CD25-deficient LN-TRCs exhibit attenuated STAT5 phosphorylation in naive CD4+ T cells during T cell differentiation, promoting T helper 17 (Th17) cell differentiation and Th17 response-related gene expression. In experimental autoimmune disease models, disease severity was elevated in mice lacking CD25 in LN-TRCs. Therefore, our results suggest that CD25 expression on LN-TRCs regulates CD4+ T cell differentiation by modulating early IL-2 signaling of neighboring, naive CD4+ T cells, influencing the overall properties of immune responses. © 2022 Kim et al. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | Rockefeller University Press | - |
dc.title | Lymph node fibroblastic reticular cells regulate differentiation and function of CD4 T cells via CD25 | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, K.-M. | - |
dc.identifier.doi | 10.1084/jem.20200795 | - |
dc.identifier.scopusid | 2-s2.0-85126908002 | - |
dc.identifier.wosid | 000860474100001 | - |
dc.identifier.bibliographicCitation | Journal of Experimental Medicine, v.219, no.5 | - |
dc.relation.isPartOf | Journal of Experimental Medicine | - |
dc.citation.title | Journal of Experimental Medicine | - |
dc.citation.volume | 219 | - |
dc.citation.number | 5 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Research & Experimental Medicine | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Medicine, Research & Experimental | - |
dc.subject.keywordPlus | ACTIVATION | - |
dc.subject.keywordPlus | CYTOKINE | - |
dc.subject.keywordPlus | DENDRITIC CELLS | - |
dc.subject.keywordPlus | HOMEOSTASIS | - |
dc.subject.keywordPlus | IL-2 | - |
dc.subject.keywordPlus | IN-VITRO | - |
dc.subject.keywordPlus | INDUCTION | - |
dc.subject.keywordPlus | INTERLEUKIN (IL)-2 | - |
dc.subject.keywordPlus | RECEPTOR-BETA-CHAIN | - |
dc.subject.keywordPlus | TH17 CELLS | - |
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