The effect of a fennel seed extract on the STAT signaling and intestinal barrier function
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Das, Barun | - |
dc.contributor.author | Rabalais, John | - |
dc.contributor.author | Kozan, Philip | - |
dc.contributor.author | Lu, Tina | - |
dc.contributor.author | Durali, Nassim | - |
dc.contributor.author | Okamoto, Kevin | - |
dc.contributor.author | McGeough, Matthew D. | - |
dc.contributor.author | Lee, Beom Jae | - |
dc.contributor.author | Barrett, Kim E. | - |
dc.contributor.author | Marchelletta, Ronald | - |
dc.contributor.author | Sivagnanam, Mamata | - |
dc.date.accessioned | 2022-10-06T11:42:07Z | - |
dc.date.available | 2022-10-06T11:42:07Z | - |
dc.date.created | 2022-10-06 | - |
dc.date.issued | 2022-07-08 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/144113 | - |
dc.description.abstract | Background Foeniculum vulgare, F. vulgare, commonly known as fennel, is believed to be one of the world's oldest medicinal herbs and has been exploited by people for centuries as a nutritional aid for digestive disorders. In many southeast Asian countries, it is ingested as an after-meal snack, mukhvas, due to its breath-freshening and digestive aid properties. F. vulgare is used in some countries, such as Iran, as a complementary and alternative treatment for inflammatory bowel disease (IBD). Methods This study investigated the effects of fennel seed extract on intestinal epithelium barrier function and the Signal Transducer and Activator of Transcription (STAT) pathway. This pathway is active in inflammatory bowel disease. To study the protective effects of fennel seed extract in vitro, monolayers derived from the T84 colonic cell line were challenged with interferon-gamma (IFN-gamma) and monitored with and without fennel seed extract. To complement our in vitro studies, the dextran sodium sulfate induced murine colitis model was employed to ascertain whether the protective effect of fennel seed extract can be recapitulated in vivo. Results Fennel seed extract was shown to exert a protective effect on transepithelial electrical resistance (TEER) in both T84 and murine models and showed increases in tight junction-associated mRNA in T84 cell monolayers. Both models demonstrated significant decreases in phosphorylated STAT1 (pSTAT1), indicating reduced activation of the STAT pathway. Additionally, mice treated with fennel seed showed significantly lower ulcer indices than control mice. Conclusions We conclude barrier function of the gastrointestinal tract is improved by fennel seed extract, suggesting the potential utility of this agent as an alternative or adjunctive therapy in IBD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | PUBLIC LIBRARY SCIENCE | - |
dc.subject | TUMOR-NECROSIS-FACTOR | - |
dc.subject | INTERFERON-GAMMA | - |
dc.subject | ULCERATIVE-COLITIS | - |
dc.subject | EPITHELIAL-CELLS | - |
dc.subject | ESSENTIAL OIL | - |
dc.subject | T-BET | - |
dc.subject | ANETHOLE | - |
dc.subject | PERMEABILITY | - |
dc.subject | EXPRESSION | - |
dc.subject | PATHOGENESIS | - |
dc.title | The effect of a fennel seed extract on the STAT signaling and intestinal barrier function | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Beom Jae | - |
dc.identifier.doi | 10.1371/journal.pone.0271045 | - |
dc.identifier.scopusid | 2-s2.0-85133722441 | - |
dc.identifier.wosid | 000844536800104 | - |
dc.identifier.bibliographicCitation | PLOS ONE, v.17, no.7 | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.citation.title | PLOS ONE | - |
dc.citation.volume | 17 | - |
dc.citation.number | 7 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Science & Technology - Other Topics | - |
dc.relation.journalWebOfScienceCategory | Multidisciplinary Sciences | - |
dc.subject.keywordPlus | ANETHOLE | - |
dc.subject.keywordPlus | EPITHELIAL-CELLS | - |
dc.subject.keywordPlus | ESSENTIAL OIL | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | INTERFERON-GAMMA | - |
dc.subject.keywordPlus | PATHOGENESIS | - |
dc.subject.keywordPlus | PERMEABILITY | - |
dc.subject.keywordPlus | T-BET | - |
dc.subject.keywordPlus | TUMOR-NECROSIS-FACTOR | - |
dc.subject.keywordPlus | ULCERATIVE-COLITIS | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.