Novel Regulators of Macropinocytosis-Dependent Growth Revealed by Informer Set Library Screening in Pancreatic Cancer Cellsopen access
- Authors
- Kim, S.H.; Song, J.H.; Kim, M.J.; Song, M.G.; Ku, A.A.; Bandyopadhyay, S.; McCormick, F.; Kim, S.E.
- Issue Date
- 9월-2022
- Publisher
- MDPI
- Keywords
- Informer set library screening; cancer metabolism; macropinocytosis; nutrient scavenging; pancreatic cancer
- Citation
- Metabolites, v.12, no.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Metabolites
- Volume
- 12
- Number
- 9
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/144173
- DOI
- 10.3390/metabo12090831
- ISSN
- 2218-1989
- Abstract
- Cancer cells utilize multiple nutrient scavenging mechanisms to support growth and survival in nutrient-poor, hypoxic tumor microenvironments. Among these mechanisms, macropinocytosis has emerged as an important pathway of extracellular nutrient acquisition in cancer cells, particularly in tumors with activated RAS signaling, such as pancreatic cancer. However, the absence of a clinically available inhibitor, as well as the gap of knowledge in macropinocytosis regulation, remain a hurdle for its use for cancer therapy. Here, we use the Informer set library to identify novel regulators of macropinocytosis-dependent growth in pancreatic cancer cells. Understanding how these regulators function will allow us to provide novel opportunities for therapeutic intervention. © 2022 by the authors.
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Collections - College of Health Sciences > School of Biosystems and Biomedical Sciences > 1. Journal Articles
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