Plasmon-Triggered Upconversion Emissions and Hot Carrier Injection for Combinatorial Photothermal and Photodynamic Cancer Therapy
- Authors
- Yu, Subin; Jang, Dohyub; Yuan, Hong; Huang, Wen-Tse; Kim, Minju; Mota, Filipe Marques; Liu, Ru-Shi; Lee, Hyukjin; Kim, Sehoon; Kim, Dong Ha
- Issue Date
- 15-12월-2021
- Publisher
- AMER CHEMICAL SOC
- Keywords
- upconversion; localized surface plasmon resonance; titanium dioxide; photosensitizer; phototherapy
- Citation
- ACS APPLIED MATERIALS & INTERFACES, v.13, no.49, pp.58422 - 58433
- Indexed
- SCIE
SCOPUS
- Journal Title
- ACS APPLIED MATERIALS & INTERFACES
- Volume
- 13
- Number
- 49
- Start Page
- 58422
- End Page
- 58433
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/144606
- DOI
- 10.1021/acsami.1c21949
- ISSN
- 1944-8244
- Abstract
- Despite the unique ability of lanthanide-doped upconversion nanoparticles (UCNPs) to convert near-infrared (NIR) light to high-energy UV-vis radiation, low quantum efficiency has rendered their application unpractical in biomedical fields. Here, we report anatase titania-coated plasmonic gold nanorods decorated with UCNPs (Au NR@aTiO(2)@UCNPs) for combinational photothermal and photodynamic therapy to treat cancer. Our novel architecture employs the incorporation of an anatase titanium dioxide (aTiO(2)) photosensitizer as a spacer and exploits the localized surface plasmon resonance (LSPR) properties of the Au core. The LSPR-derived near-field enhancement induces a threefold boost of upconversion emissions, which are re-absorbed by neighboring aTiO(2) and Au nanocomponents. Photocatalytic experiments strongly infer that LSPR-induced hot electrons are injected into the conduction band of aTiO(2), generating reactive oxygen species. As phototherapeutic agents, our hybrid nanostructures show remarkable in vitro anticancer effect under NIR light [28.0% cancer cell viability against Au NR@aTiO(2) (77.3%) and UCNP@aTiO(2) (98.8%)] ascribed to the efficient radical formation and LSPR-induced heat generation, with cancer cell death primarily following an apoptotic pathway. In vivo animal studies further confirm the tumor suppression ability of Au NR@aTiO(2)@UCNPs through combinatorial photothermal and photodynamic effect. Our hybrid nanomaterials emerge as excellent multifunctional phototherapy agent, providing a valuable addition to light-triggered cancer treatments in deep tissue.
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