Heart failure with mid-range ejection fraction and the effect of beta-blockers after acute myocardial infarction
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Song, Pil Sang | - |
dc.contributor.author | Kim, Mijoo | - |
dc.contributor.author | Seong, Seok-Woo | - |
dc.contributor.author | Park, Jae-Hyeong | - |
dc.contributor.author | Choi, Si Wan | - |
dc.contributor.author | Hahn, Joo-Yong | - |
dc.contributor.author | Gwon, Hyeon-Cheol | - |
dc.contributor.author | Hur, Seung-Ho | - |
dc.contributor.author | Rha, Seung-Woon | - |
dc.contributor.author | Yoon, Chang-Hwan | - |
dc.contributor.author | Jeong, Myung Ho | - |
dc.contributor.author | Seong, In-Whan | - |
dc.contributor.author | Jeong, Jin-Ok | - |
dc.date.accessioned | 2022-11-04T04:41:34Z | - |
dc.date.available | 2022-11-04T04:41:34Z | - |
dc.date.created | 2022-11-04 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 0910-8327 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/144610 | - |
dc.description.abstract | There is currently an ongoing debate about the 'grey area' of heart failure with mid-range ejection fraction (HFmrEF). We evaluated characteristics, prognosis, and the effect of beta-blockers on clinical outcomes in patients with HFmrEF after acute myocardial infarction (AMI). We included a total of 10,785 patients and divided them into three groups: EF 40-49% (HFmrEF; n = 2717; reference); EF < 40% (reduced EF [HFrEF]; n = 1194); and EF >= 50% (preserved EF [HFpEF]; n = 6874). The primary outcome was 2-year all-cause mortality. HFmrEF was intermediate between HFrEF and HFpEF for baseline characteristics. The risk of all-cause mortality was lower for HFmrEF patients compared to HFrEF patients (adjusted hazard ratio [HR] 0.710; 95% confidence interval [CI] 0.544-0.927; P = 0.012). However, HFmrEF patients tended to be at higher risk for 2-year all-cause mortality than HFpEF patients (adjusted HR 1.235; 95% CI 0.989-1.511; P = 0.090). beta-blockers were associated with reductions in all-cause mortality for the entire cohort (adjusted HR 0.760; 95% CI 0.592-0.975; P = 0.031). beta-blockers were effective in patients with HFrEF (adjusted HR 0.667; 95% CI 0.471-0.944; P = 0.022), tended to be effective in patients with HFmrEF (adjusted HR 0.665; 95% CI 0.426-1.038; P = 0.072), but not effective in patients with HFpEF (adjusted HR 0.852; 95% CI 0.548-1.326; P = 0.478; interaction P = 0.026). In conclusion, clinical profiles and prognosis of patients with post-AMI HFmrEF are largely intermediate between HFrEF and HFpEF. beta-blockers reduced or tended to reduce 2-year all-cause mortality in patients with HFrEF or HFmrEF, respectively, but not those with HFpEF after AMI. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGER | - |
dc.subject | CLINICAL-OUTCOMES | - |
dc.subject | GUIDELINES | - |
dc.subject | THERAPY | - |
dc.title | Heart failure with mid-range ejection fraction and the effect of beta-blockers after acute myocardial infarction | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Rha, Seung-Woon | - |
dc.identifier.doi | 10.1007/s00380-021-01876-1 | - |
dc.identifier.scopusid | 2-s2.0-85106403021 | - |
dc.identifier.wosid | 000652907500002 | - |
dc.identifier.bibliographicCitation | HEART AND VESSELS, v.36, no.12, pp.1848 - 1855 | - |
dc.relation.isPartOf | HEART AND VESSELS | - |
dc.citation.title | HEART AND VESSELS | - |
dc.citation.volume | 36 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 1848 | - |
dc.citation.endPage | 1855 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Peripheral Vascular Disease | - |
dc.subject.keywordPlus | CLINICAL-OUTCOMES | - |
dc.subject.keywordPlus | GUIDELINES | - |
dc.subject.keywordPlus | THERAPY | - |
dc.subject.keywordAuthor | Heart failure with mid-range ejection fraction | - |
dc.subject.keywordAuthor | Acute myocardial infarction | - |
dc.subject.keywordAuthor | & | - |
dc.subject.keywordAuthor | #946 | - |
dc.subject.keywordAuthor | -blockers | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.