Real-world experience of afatinib as first-line therapy for advanced EGFR mutation-positive non-small cell lung cancer in Korea
DC Field | Value | Language |
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dc.contributor.author | Lee, Sung Yong | - |
dc.contributor.author | Choi, Chang-Min | - |
dc.contributor.author | Chang, Yoon Soo | - |
dc.contributor.author | Lee, Kye Young | - |
dc.contributor.author | Kim, Seung Joon | - |
dc.contributor.author | Yang, Sei Hoon | - |
dc.contributor.author | Ryu, Jeong Seon | - |
dc.contributor.author | Lee, Jeong Eun | - |
dc.contributor.author | Lee, Shin Yup | - |
dc.contributor.author | Park, Ji Young | - |
dc.contributor.author | Kim, Young-Chul | - |
dc.contributor.author | Oh, In-Jae | - |
dc.contributor.author | Jung, Chi Young | - |
dc.contributor.author | Lee, Sang Hoon | - |
dc.contributor.author | Yoon, Seong Hoon | - |
dc.contributor.author | Choi, Juwhan | - |
dc.contributor.author | Jang, Tae Won | - |
dc.date.accessioned | 2022-11-04T04:42:28Z | - |
dc.date.available | 2022-11-04T04:42:28Z | - |
dc.date.created | 2022-11-04 | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2218-6751 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/144614 | - |
dc.description.abstract | Background: We investigated the clinical characteristics and treatment outcomes of Korean patients receiving first-line afatinib for advanced epidermal growth factor receptor mutation-positive (EGFRm(+)) non-small cell lung cancer (NSCLC) in a real-world setting. Methods: Electronic case reports were retrospectively reviewed from patients across 15 sites in South Korea. Outcome measures included baseline characteristics, overall response rate (ORR), time-to-treatment discontinuation (TTD), and overall survival (OS). Subgroups were: presence/absence of brain metastases at baseline, dose reductions, and baseline EGFR mutation category. Results: Among 422 patients, 39.8% had brain metastases and 59.0%/25.1%/10.0%/5.0% had Del19/L858R/compound/uncommon EGFR mutations at baseline. ORR was 62.6% overall; responses were observed across all EGFR mutation categories, including against compound mutations. Median TTD was 17.8 months; median OS was not reached (NR). Median TTD and OS were longer in patients without versus with brain metastases (TTD: 22.9 vs. 14.8 months, P=0.001; OS: NR vs. 40.3 months, P=0.0009) and patients with versus without dose reductions (TTD: 22.2 vs. 14.2 months, P=0.0004; OS: NR vs. 40.3 months, P=0.0117). Median OS was 30.5/37.7 months in patients receiving chemotherapy/osimertinib as subsequent therapy. The most common treatment-related adverse events (TRAEs; any grade/grade >= 3) were diarrhea (31.3%/8.5%) and rash (23.0%/8.1%). Overall, 34 patients (8.1%) discontinued afatinib due to A Es. Conclusions: Afatinib was well tolerated with no new safety signals, and efficacy was encouraging in Korean patients with EGFRm(+) NSCLC, including those with baseline brain metastases and/or uncommon EGFR mutations. AE management with dose reductions facilitated a long TTD, prolonging the chemotherapy-free period for many patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | AME PUBL CO | - |
dc.subject | GROWTH-FACTOR RECEPTOR | - |
dc.subject | SURVIVAL-DATA | - |
dc.subject | OPEN-LABEL | - |
dc.subject | ADENOCARCINOMA | - |
dc.subject | GEFITINIB | - |
dc.subject | OSIMERTINIB | - |
dc.subject | ERLOTINIB | - |
dc.subject | NSCLC | - |
dc.subject | CHEMOTHERAPY | - |
dc.subject | EXON-19 | - |
dc.title | Real-world experience of afatinib as first-line therapy for advanced EGFR mutation-positive non-small cell lung cancer in Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Sung Yong | - |
dc.identifier.doi | 10.21037/tlcr-21-501 | - |
dc.identifier.scopusid | 2-s2.0-85123013641 | - |
dc.identifier.wosid | 000729644100001 | - |
dc.identifier.bibliographicCitation | TRANSLATIONAL LUNG CANCER RESEARCH, v.10, no.12, pp.4353 - + | - |
dc.relation.isPartOf | TRANSLATIONAL LUNG CANCER RESEARCH | - |
dc.citation.title | TRANSLATIONAL LUNG CANCER RESEARCH | - |
dc.citation.volume | 10 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 4353 | - |
dc.citation.endPage | + | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Oncology | - |
dc.relation.journalResearchArea | Respiratory System | - |
dc.relation.journalWebOfScienceCategory | Oncology | - |
dc.relation.journalWebOfScienceCategory | Respiratory System | - |
dc.subject.keywordPlus | GROWTH-FACTOR RECEPTOR | - |
dc.subject.keywordPlus | SURVIVAL-DATA | - |
dc.subject.keywordPlus | OPEN-LABEL | - |
dc.subject.keywordPlus | ADENOCARCINOMA | - |
dc.subject.keywordPlus | GEFITINIB | - |
dc.subject.keywordPlus | OSIMERTINIB | - |
dc.subject.keywordPlus | ERLOTINIB | - |
dc.subject.keywordPlus | NSCLC | - |
dc.subject.keywordPlus | CHEMOTHERAPY | - |
dc.subject.keywordPlus | EXON-19 | - |
dc.subject.keywordAuthor | Afatinib | - |
dc.subject.keywordAuthor | epidermal growth factor receptor (EGFR) | - |
dc.subject.keywordAuthor | first-line | - |
dc.subject.keywordAuthor | non-small cell lung cancer (NSCLC) | - |
dc.subject.keywordAuthor | real-world | - |
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