Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification
DC Field | Value | Language |
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dc.contributor.author | Yun, J. | - |
dc.contributor.author | Jeong, Y. | - |
dc.contributor.author | Nam, O. | - |
dc.contributor.author | Yeo, K.B. | - |
dc.contributor.author | Jo, Y.K. | - |
dc.contributor.author | Heo, H.R. | - |
dc.contributor.author | Kim, C.S. | - |
dc.contributor.author | Joo, K.I. | - |
dc.contributor.author | Pack, S.P. | - |
dc.contributor.author | Jin, E. | - |
dc.contributor.author | Cha, H.J. | - |
dc.date.accessioned | 2022-11-05T11:42:05Z | - |
dc.date.available | 2022-11-05T11:42:05Z | - |
dc.date.created | 2022-11-04 | - |
dc.date.issued | 2021 | - |
dc.identifier.issn | 2576-6422 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/144832 | - |
dc.description.abstract | Bone graft materials have been mainly developed based on inorganic materials, including calcium phosphate. However, these graft materials usually act as osteoconductive rather than osteoinductive scaffolds. To improve bone reconstruction, a combination of several materials has been proposed. However, there are still no alternatives that can completely replace the existing animal-derived bone graft materials. In this work, a marine-inspired biomineral complex was suggested as a potential bone graft material. The proposed biosilicified coccolithophore-derived coccoliths using bioengineered mussel adhesive proteins show osteopromotive ability through the synergistic effects of osteoconductivity from calcium carbonate and osteoinductivity from silica. Its possibility of use as a bone substitute was determined by evaluating the in vitro osteogenic behaviors of multipotent mesenchymal stem cells and in vivo bone regeneration in a rat calvarial defect model. Therefore, the marine-inspired biomineral complex developed in this study could be successfully used for bone tissue engineering. © 2021 American Chemical Society. All rights reserved. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.title | Bone Graft Biomineral Complex Coderived from Marine Biocalcification and Biosilicification | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Pack, S.P. | - |
dc.identifier.doi | 10.1021/acsabm.1c00346 | - |
dc.identifier.scopusid | 2-s2.0-85111283874 | - |
dc.identifier.bibliographicCitation | ACS Applied Bio Materials, v.4, no.8, pp.6046 - 6055 | - |
dc.relation.isPartOf | ACS Applied Bio Materials | - |
dc.citation.title | ACS Applied Bio Materials | - |
dc.citation.volume | 4 | - |
dc.citation.number | 8 | - |
dc.citation.startPage | 6046 | - |
dc.citation.endPage | 6055 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scopus | - |
dc.subject.keywordAuthor | biomineral | - |
dc.subject.keywordAuthor | biosilica | - |
dc.subject.keywordAuthor | bone regeneration | - |
dc.subject.keywordAuthor | bone substitutes | - |
dc.subject.keywordAuthor | coccoliths | - |
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