Neurodynamic correlates for the cross-frequency coupled transcranial alternating current stimulation during working memory performanceopen access
- Authors
- Kim, Seong-Eun; Kim, Hyun-Seok; Kwak, Youngchul; Ahn, Min-Hee; Choi, Kyung Mook; Min, Byoung-Kyong
- Issue Date
- 3-10월-2022
- Publisher
- FRONTIERS MEDIA SA
- Keywords
- neuromodulation; nodal efficiency; transcranial alternating current stimulation (tACS); working memory; cross-frequency coupling (CFC)
- Citation
- FRONTIERS IN NEUROSCIENCE, v.16
- Indexed
- SCIE
SCOPUS
- Journal Title
- FRONTIERS IN NEUROSCIENCE
- Volume
- 16
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/145487
- DOI
- 10.3389/fnins.2022.1013691
- ISSN
- 1662-4548
- Abstract
- Transcranial current stimulation is a neuromodulation technique used to modulate brain oscillations and, in turn, to enhance human cognitive function in a non-invasive manner. This study investigated whether cross-frequency coupled transcranial alternating current stimulation (CFC-tACS) improved working memory performance. Participants in both the tACS-treated and sham groups were instructed to perform a modified Sternberg task, where a combination of letters and digits was presented. Theta-phase/high-gamma-amplitude CFC-tACS was administered over electrode F3 and its four surrounding return electrodes (Fp1, Fz, F7, and C3) for 20 min. To identify neurophysiological correlates for the tACS-mediated enhancement of working memory performance, we analyzed EEG alpha and theta power, cross-frequency coupling, functional connectivity, and nodal efficiency during the retention period of the working memory task. We observed significantly reduced reaction times in the tACS-treated group, with suppressed treatment-mediated differences in frontal alpha power and unidirectional Fz-delta-phase to Oz-high-gamma-amplitude modulation during the second half of the retention period when network analyses revealed tACS-mediated fronto-occipital dissociative neurodynamics between alpha suppression and delta/theta enhancement. These findings indicate that tACS modulated top-down control and functional connectivity across the fronto-occipital regions, resulting in improved working memory performance. Our observations are indicative of the feasibility of enhancing cognitive performance by the CFC-formed tACS.
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Collections - Graduate School > Department of Brain and Cognitive Engineering > 1. Journal Articles
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