Synthesis of 7,2 '-Dihydroxy-4 ',5 '-Dimethoxyisoflavanone, a Phytoestrogen with Derma Papilla Cell Proliferative Activity
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Taewoo | - |
dc.contributor.author | Kim, Hyun Su | - |
dc.contributor.author | Jang, Jaebong | - |
dc.contributor.author | Kim, Dong-Jun | - |
dc.contributor.author | Lee, Jongkook | - |
dc.contributor.author | Lee, Dongjoo | - |
dc.contributor.author | Kim, Seok-Ho | - |
dc.date.accessioned | 2022-11-15T19:40:25Z | - |
dc.date.available | 2022-11-15T19:40:25Z | - |
dc.date.created | 2022-11-15 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 1420-3049 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145510 | - |
dc.description.abstract | This paper reports a concise and scalable method for the synthesis of the phytoestrogen 7,2 '-dihydroxy-4 ',5 '-dimethoxyisoflavanone 1 via an optimized synthetic route. Compound 1 was readily obtained in 11 steps and 11% overall yield on a gram scale from commercially available 3,4-dimethoxyphenol. The key features of the synthesis include the construction of the deoxybenzoin unit through a sequence of Claisen rearrangement, oxidative cleavage, and aryllithium addition and the efficient synthesis of the isoflavanone architecture from highly functionalized 2-hydroxyketone. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.title | Synthesis of 7,2 '-Dihydroxy-4 ',5 '-Dimethoxyisoflavanone, a Phytoestrogen with Derma Papilla Cell Proliferative Activity | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Jang, Jaebong | - |
dc.identifier.doi | 10.3390/molecules27196660 | - |
dc.identifier.scopusid | 2-s2.0-85140015927 | - |
dc.identifier.wosid | 000868034800001 | - |
dc.identifier.bibliographicCitation | MOLECULES, v.27, no.19 | - |
dc.relation.isPartOf | MOLECULES | - |
dc.citation.title | MOLECULES | - |
dc.citation.volume | 27 | - |
dc.citation.number | 19 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordAuthor | phytoestrogen | - |
dc.subject.keywordAuthor | isoflavanone | - |
dc.subject.keywordAuthor | Dalbergia oliveri | - |
dc.subject.keywordAuthor | hair growth | - |
dc.subject.keywordAuthor | deoxybenzoin | - |
dc.subject.keywordAuthor | total synthesis | - |
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