Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide cohort study comparing three COVID-19 vaccination protocols in South Korea
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Nham, Eliel | - |
dc.contributor.author | Ko, Jae-Hoon | - |
dc.contributor.author | Song, Kyoung-Ho | - |
dc.contributor.author | Choi, Ju-Yeon | - |
dc.contributor.author | Kim, Eu Suk | - |
dc.contributor.author | Kim, Hye-Jin | - |
dc.contributor.author | Kim, Byoungguk | - |
dc.contributor.author | Lim, Hee-Young | - |
dc.contributor.author | Kim, Kyung-Chang | - |
dc.contributor.author | Jang, Hee-Chang | - |
dc.contributor.author | Lee, Kyoung Hwa | - |
dc.contributor.author | Song, Young Goo | - |
dc.contributor.author | Baek, Yae Jee | - |
dc.contributor.author | Ahn, Jin Young | - |
dc.contributor.author | Choi, Jun Yong | - |
dc.contributor.author | Kim, Yong Chan | - |
dc.contributor.author | Park, Yoon Soo | - |
dc.contributor.author | Choi, Won Suk | - |
dc.contributor.author | Bae, Seongman | - |
dc.contributor.author | Kim, Sung-Han | - |
dc.contributor.author | Kang, Eun-Suk | - |
dc.contributor.author | Jeong, Hye Won | - |
dc.contributor.author | Kim, Shin-Woo | - |
dc.contributor.author | Kwon, Ki Tae | - |
dc.contributor.author | Kim, Sung Soon | - |
dc.contributor.author | Peck, Kyong Ran | - |
dc.date.accessioned | 2022-11-16T00:40:17Z | - |
dc.date.available | 2022-11-16T00:40:17Z | - |
dc.date.created | 2022-11-15 | - |
dc.date.issued | 2022-09-23 | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145535 | - |
dc.description.abstract | IntroductionDespite vaccine development, the COVID-19 pandemic is ongoing due to immunity-escaping variants of concern (VOCs). Estimations of vaccine-induced protective immunity against VOCs are essential for setting proper COVID-19 vaccination policy. MethodsWe performed plaque-reduction neutralizing tests (PRNTs) using sera from healthcare workers (HCWs) collected from baseline to six months after COVID-19 vaccination and from convalescent COVID-19 patients. The 20.2% of the mean PRNT titer of convalescent sera was used as 50% protective value, and the percentage of HCWs with protective immunity for each week (percent-week) was compared among vaccination groups. A correlation equation was deduced between a PRNT 50% neutralizing dose (ND50) against wild type (WT) SARS-CoV-2 and that of the Delta variant. ResultsWe conducted PRNTs on 1,287 serum samples from 297 HCWs (99 HCWs who received homologous ChAdOx1 vaccination (ChAd), 99 from HCWs who received homologous BNT162b2 (BNT), and 99 from HCWs who received heterologous ChAd followed by BNT (ChAd-BNT)). Using 365 serum samples from 116 convalescent COVID-19 patients, PRNT ND50 of 118.25 was derived as 50% protective value. The 6-month cumulative percentage of HCWs with protective immunity against WT SARS-CoV-2 was highest in the BNT group (2297.0 percent-week), followed by the ChAd-BNT (1576.8) and ChAd (1403.0) groups. In the inter-group comparison, protective percentage of the BNT group (median 96.0%, IQR 91.2-99.2%) was comparable to the ChAd-BNT group (median 85.4%, IQR 15.7-100%; P =0.117) and significantly higher than the ChAd group (median 60.1%, IQR 20.0-87.1%; P <0.001). When Delta PRNT was estimated using the correlation equation, protective immunity at the 6-month waning point was markedly decreased (28.3% for ChAd group, 52.5% for BNT, and 66.7% for ChAd-BNT). ConclusionDecreased vaccine-induced protective immunity at the 6-month waning point and lesser response against the Delta variant may explain the Delta-dominated outbreak of late 2021. Follow-up studies for newly-emerging VOCs would also be needed. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.title | Kinetics of vaccine-induced neutralizing antibody titers and estimated protective immunity against wild-type SARS-CoV-2 and the Delta variant: A prospective nationwide cohort study comparing three COVID-19 vaccination protocols in South Korea | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Won Suk | - |
dc.identifier.doi | 10.3389/fimmu.2022.968105 | - |
dc.identifier.scopusid | 2-s2.0-85139395102 | - |
dc.identifier.wosid | 000865020400001 | - |
dc.identifier.bibliographicCitation | FRONTIERS IN IMMUNOLOGY, v.13 | - |
dc.relation.isPartOf | FRONTIERS IN IMMUNOLOGY | - |
dc.citation.title | FRONTIERS IN IMMUNOLOGY | - |
dc.citation.volume | 13 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.subject.keywordAuthor | protective immunity | - |
dc.subject.keywordAuthor | vaccination | - |
dc.subject.keywordAuthor | neutralizing antibody | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | COVID-19 | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
(02841) 서울특별시 성북구 안암로 14502-3290-1114
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.