Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig modelopen accessRotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model

Other Titles
Rotational intraperitoneal pressurized aerosol chemotherapy with paclitaxel and cisplatin: pharmacokinetics, tissue concentrations, and toxicities in a pig model
Authors
Park, Soo JinLee, Eun JiSeol, AeranPark, SunwooHam, JiyeonYim, Ga WonShim, Seung-HyukLim, WhasunChang, Suk-JoonSong, GwonhwaPark, Ji WonKim, Hee Seung
Issue Date
9월-2022
Publisher
KOREAN SOC GYNECOLOGY ONCOLOGY & COLPOSCOPY
Keywords
Aerosol; Cisplatin; Drug Delivery Systems; Paclitaxel; Peritoneal Neoplasms; Pharmacokinetics
Citation
JOURNAL OF GYNECOLOGIC ONCOLOGY, v.33, no.5, pp.1 - 12
Indexed
SCIE
SCOPUS
KCI
Journal Title
JOURNAL OF GYNECOLOGIC ONCOLOGY
Volume
33
Number
5
Start Page
1
End Page
12
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/145541
DOI
10.3802/jgo.2022.33.e56
ISSN
2005-0380
Abstract
Objective: We used paclitaxel and cisplatin, known to be effective in intraperitoneal chemotherapy, in a novel prototype of rotational intraperitoneal pressurized aerosol chemotherapy (RIPAC) and evaluated the pharmacokinetics, tissue concentrations, and toxicities in a pig model. Methods: We developed RIPAC, including the nozzle with the conical pendulum motion, and used 10% of intravenous doses of paclitaxel and cisplatin. We used high-performance liquid chromatography followed by tandem mass spectrometry to analyze serum and tissue concentrations. We applied a non-compartment model to study pharmacokinetics to analyze the time-dependent serum concentrations measured before RIPAC to 48 hours. We evaluated the difference in tissue concentrations between twelve peritoneal regions by the modified peritoneal cancer index. For evaluating toxicities, we observed hepatic and renal function until 4 days after RIPAC. Results: Six pigs underwent RIPAC using paclitaxel (n=3) and cisplatin (n=3). The peak serum concentration (C-max) and the area tinder the curve were higher for cisplatin, while the time to the peak serum concentration (T-max) was longer for paclitaxel. Moreover, the parietal peritoneum showed higher tissue concentrations than the visceral peritoneum, and the ratio of tissue to serum concentrations using C-max was higher for paclitaxel (172.2-6,237.9) than for cisplatin (0.1-9.3). However, there were no renal and hepatic toxicities after RIPAC with paclitaxel or cisplatin. Conclusion: Delayed absorption of paclitaxel sprayed by RIPAC into the peritoneum to the bloodstream may lead to higher tissue concentrations at different regions and lower serum concentrations than cisplatin.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Gwon hwa photo

Song, Gwon hwa
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE