Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jang, Wooyoung Eric | - |
dc.contributor.author | Park, Ji Hwan | - |
dc.contributor.author | Park, Gaeun | - |
dc.contributor.author | Bang, Geul | - |
dc.contributor.author | Na, Chan Hyun | - |
dc.contributor.author | Kim, Jin Young | - |
dc.contributor.author | Kim, Kwang-Youl | - |
dc.contributor.author | Kim, Kwang Pyo | - |
dc.contributor.author | Shin, Chan Young | - |
dc.contributor.author | An, Joon-Yong | - |
dc.contributor.author | Lee, Yong-Seok | - |
dc.contributor.author | Kim, Min-Sik | - |
dc.date.accessioned | 2022-11-16T05:41:27Z | - |
dc.date.available | 2022-11-16T05:41:27Z | - |
dc.date.created | 2022-11-15 | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 1359-4184 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145577 | - |
dc.description.abstract | Autism spectrum disorder (ASD) is a major neurodevelopmental disorder in which patients present with core symptoms of social communication impairment, restricted interest, and repetitive behaviors. Although various studies have been performed to identify ASD-related mechanisms, ASD pathology is still poorly understood. CNTNAP2 genetic variants have been found that represent ASD genetic risk factors, and disruption of Cntnap2 expression has been associated with ASD phenotypes in mice. In this study, we performed an integrative multi-omics analysis by combining quantitative proteometabolomic data obtained with Cntnap2 knockout (KO) mice with multi-omics data obtained from ASD patients and forebrain organoids to elucidate Cntnap2-dependent molecular networks in ASD. To this end, a mass spectrometry-based proteometabolomic analysis of the medial prefrontal cortex in Cntnap2 KO mice led to the identification of Cntnap2-associated molecular features, and these features were assessed in combination with multi-omics data obtained on the prefrontal cortex in ASD patients to identify bona fide ASD cellular processes. Furthermore, a reanalysis of single-cell RNA sequencing data obtained from forebrain organoids derived from patients with CNTNAP2-associated ASD revealed that the aforementioned identified ASD processes were mainly linked to excitatory neurons. On the basis of these data, we constructed Cntnap2-associated ASD network models showing mitochondrial dysfunction, axonal impairment, and synaptic activity. Our results may shed light on the Cntnap2-dependent molecular networks in ASD. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | SPRINGERNATURE | - |
dc.subject | MOUSE MODELS | - |
dc.subject | GENE-EXPRESSION | - |
dc.subject | CNTNAP2 | - |
dc.subject | NEURODEGENERATION | - |
dc.subject | PHOSPHORYLATION | - |
dc.subject | CONNECTIVITY | - |
dc.subject | EPILEPSY | - |
dc.subject | GTPASES | - |
dc.subject | CASPR2 | - |
dc.subject | RAC | - |
dc.title | Cntnap2-dependent molecular networks in autism spectrum disorder revealed through an integrative multi-omics analysis | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | An, Joon-Yong | - |
dc.identifier.doi | 10.1038/s41380-022-01822-1 | - |
dc.identifier.scopusid | 2-s2.0-85140004388 | - |
dc.identifier.wosid | 000868959900004 | - |
dc.identifier.bibliographicCitation | MOLECULAR PSYCHIATRY | - |
dc.relation.isPartOf | MOLECULAR PSYCHIATRY | - |
dc.citation.title | MOLECULAR PSYCHIATRY | - |
dc.type.rims | ART | - |
dc.type.docType | Article; Early Access | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Neurosciences & Neurology | - |
dc.relation.journalResearchArea | Psychiatry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Neurosciences | - |
dc.relation.journalWebOfScienceCategory | Psychiatry | - |
dc.subject.keywordPlus | MOUSE MODELS | - |
dc.subject.keywordPlus | GENE-EXPRESSION | - |
dc.subject.keywordPlus | CNTNAP2 | - |
dc.subject.keywordPlus | NEURODEGENERATION | - |
dc.subject.keywordPlus | PHOSPHORYLATION | - |
dc.subject.keywordPlus | CONNECTIVITY | - |
dc.subject.keywordPlus | EPILEPSY | - |
dc.subject.keywordPlus | GTPASES | - |
dc.subject.keywordPlus | CASPR2 | - |
dc.subject.keywordPlus | RAC | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
145 Anam-ro, Seongbuk-gu, Seoul, 02841, Korea+82-2-3290-2963
COPYRIGHT © 2021 Korea University. All Rights Reserved.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.