Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Bioactive molecular network-guided discovery of dihydro-?-agarofurans from the fruits of Celastrus orbiculatus

Authors
Kim, Jun GuLe, Thi Phuong LinhHan, Jae SangCho, Yong BeomKwon, HaeunLee, DonghoLee, Mi KyeongHwang, Bang Yeon
Issue Date
11월-2022
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Keywords
Celastrus orbiculatus; Celastraceae; Dihydro-3-agarofuran sesquiterpenes; Molecular networking; Melanogenesis
Citation
PHYTOCHEMISTRY, v.203
Indexed
SCIE
SCOPUS
Journal Title
PHYTOCHEMISTRY
Volume
203
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/145650
DOI
10.1016/j.phytochem.2022.113349
ISSN
0031-9422
Abstract
A bioactive molecular networking strategy has been applied to discovery of bioactive constituents from the fruits of Celastrus orbiculatus Thunb., which showed significant inhibitory effects on the alpha-MSH-induced melanin production in B16F0 melanoma cells. In the obtained molecular network, the nodes with relatively high bioactive scores were prioritized for isolation; as a result, 12 undescribed dihydro-beta-agarofuran sesquiterpenes together with 15 known compounds were isolated from MeOH extracts of the fruits of C. orbiculatus. Their structures were elucidated based on the interpretation of NMR, HRESIMS, ECD data, and single crystal X-ray diffraction. Among the obtained isolates, celastorbin A and (1R,2S,4R,5S,7S,8S,9R,10S)-1,2,8-triacetoxy-9-cinnamoyloxydihydro-/3-agarofuran, which possessed high bioactive scores in the molecular network, exhibited potent inhibitory effects on the alpha-MSH-induced melanin production in B16F0 cells with IC50 values of 4.1 and 2.0 mu M, respectively.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Plant Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Lee, Dong ho photo

Lee, Dong ho
식물생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE