Chronic exposure to butyl-paraben causes photosensitivity disruption and memory impairment in adult zebrafish
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, Jiwon L. | - |
dc.contributor.author | Kim, Seong Soon | - |
dc.contributor.author | Hwang, Kyu-Seok | - |
dc.contributor.author | Park, Hae-Chul | - |
dc.contributor.author | Cho, Sung-Hee | - |
dc.contributor.author | Bae, Myung Ae | - |
dc.contributor.author | Kim, Ki-Tae | - |
dc.date.accessioned | 2022-11-18T01:41:05Z | - |
dc.date.available | 2022-11-18T01:41:05Z | - |
dc.date.created | 2022-11-17 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0166-445X | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145704 | - |
dc.description.abstract | Limited studies on neurotoxicity following chronic exposure to butyl-paraben (BuP) have been conducted. In this study, neurobehavior in zebrafish adults was assessed using the novel tank test, photomotor response test, and T -maze test after exposure to BuP for 28 days at concentrations of 0, 0.01, 0.1, and 1.0 mg/L. To comprehensively understand the underlying molecular perturbations in the brain, alterations in transcripts, neurotransmitters, and neurosteroids were measured. We found that BuP penetrated the blood-brain barrier and impaired neuro-behavior in photosensitivity at 1.0 mg/L and in memory at 0.1 and 1.0 mg/L. RNA-seq analysis showed that phototransduction, tight junctions, and neuroactive ligand receptor activity were significantly affected, which explains the observed abnormal neurobehaviors. Neurosteroid analysis revealed that BuP increased cortisol levels in a concentration-dependent manner and specifically reduced allopregnanolone levels at all tested con-centrations, suggesting that cortisol and allopregnanolone are significant neurosteroid markers associated with photosensitivity and memory deficits. Collectively, we demonstrated that BuP can cross the blood-brain and modulate the levels of transcripts, associated with phototransduction and circadian rhythm, and neurosteroidal cortisol and allopregnanolone, resulting in abnormal neurobehavioral responses to light stimulation and learning and memory. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.subject | N-BUTYLPARABEN | - |
dc.subject | TRANSCRIPTOME | - |
dc.subject | TOXICITY | - |
dc.subject | BARRIER | - |
dc.subject | MODEL | - |
dc.title | Chronic exposure to butyl-paraben causes photosensitivity disruption and memory impairment in adult zebrafish | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Park, Hae-Chul | - |
dc.identifier.doi | 10.1016/j.aquatox.2022.106279 | - |
dc.identifier.scopusid | 2-s2.0-85136706556 | - |
dc.identifier.wosid | 000853356800001 | - |
dc.identifier.bibliographicCitation | AQUATIC TOXICOLOGY, v.251 | - |
dc.relation.isPartOf | AQUATIC TOXICOLOGY | - |
dc.citation.title | AQUATIC TOXICOLOGY | - |
dc.citation.volume | 251 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Marine & Freshwater Biology | - |
dc.relation.journalResearchArea | Toxicology | - |
dc.relation.journalWebOfScienceCategory | Marine & Freshwater Biology | - |
dc.relation.journalWebOfScienceCategory | Toxicology | - |
dc.subject.keywordPlus | N-BUTYLPARABEN | - |
dc.subject.keywordPlus | TRANSCRIPTOME | - |
dc.subject.keywordPlus | TOXICITY | - |
dc.subject.keywordPlus | BARRIER | - |
dc.subject.keywordPlus | MODEL | - |
dc.subject.keywordAuthor | Butyl-paraben | - |
dc.subject.keywordAuthor | Neurotoxicity | - |
dc.subject.keywordAuthor | Zebrafish | - |
dc.subject.keywordAuthor | Behavior | - |
dc.subject.keywordAuthor | Neurosteroid | - |
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