Duration of Humoral Immunity and Cross-Neutralizing Activity Against the Alpha, Beta, and Delta Variants After Wild-Type Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Prospective Cohort Study
DC Field | Value | Language |
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dc.contributor.author | Noh, Ji Yun | - |
dc.contributor.author | Yang, Jeong-Sun | - |
dc.contributor.author | Hwang, Soon Young | - |
dc.contributor.author | Hyun, Hakjun | - |
dc.contributor.author | Seong, Hye | - |
dc.contributor.author | Yoon, Jin Gu | - |
dc.contributor.author | Yoon, Soo-Young | - |
dc.contributor.author | Cheong, Hee Jin | - |
dc.contributor.author | Kim, Woo Joo | - |
dc.contributor.author | Park, Woo-Jung | - |
dc.contributor.author | Kim, Jun-Won | - |
dc.contributor.author | Lee, Joo-Yeon | - |
dc.contributor.author | Song, Joon Young | - |
dc.date.accessioned | 2022-11-18T08:40:56Z | - |
dc.date.available | 2022-11-18T08:40:56Z | - |
dc.date.created | 2022-11-17 | - |
dc.date.issued | 2022-09-21 | - |
dc.identifier.issn | 0022-1899 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145737 | - |
dc.description.abstract | A prospective cohort study was conducted for adults with a diagnosis of with coronavirus disease 2019 (COVID-19). Convalescent blood samples were obtained 4, 6, and 11 months after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. The seropositivity of anti-spike antibody was maintained in all patients (100%) until 11 months after COVID-19 diagnosis. Neutralizing antibody levels against wild-type SARS-CoV-2 gradually decreased but remained positive in >50% of patients 11 months after diagnosis: in 98.5% (67 of 68) at 4 months, 86.8% (46 of 53) at 6 months, and 58.8% (40 of 68) at 11 months. However, cross-neutralizing activity against the Beta and Delta variants was attenuated 2.53-fold and 2.93-fold, respectively, compared with the wild-type strain. In convalescents with mild to moderate coronavirus disease 2019, neutralizing antibody levels against wild-type severe acute respiratory syndrome coronavirus 2 gradually decreased but remained positive in >50% of patients 11 months after diagnosis. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | OXFORD UNIV PRESS INC | - |
dc.subject | LONGITUDINAL ASSESSMENT | - |
dc.title | Duration of Humoral Immunity and Cross-Neutralizing Activity Against the Alpha, Beta, and Delta Variants After Wild-Type Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Prospective Cohort Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Noh, Ji Yun | - |
dc.contributor.affiliatedAuthor | Yoon, Jin Gu | - |
dc.contributor.affiliatedAuthor | Song, Joon Young | - |
dc.identifier.doi | 10.1093/infdis/jiac050 | - |
dc.identifier.scopusid | 2-s2.0-85138459117 | - |
dc.identifier.wosid | 000767416600001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF INFECTIOUS DISEASES, v.226, no.6, pp.975 - 978 | - |
dc.relation.isPartOf | JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.title | JOURNAL OF INFECTIOUS DISEASES | - |
dc.citation.volume | 226 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 975 | - |
dc.citation.endPage | 978 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Immunology | - |
dc.relation.journalResearchArea | Infectious Diseases | - |
dc.relation.journalResearchArea | Microbiology | - |
dc.relation.journalWebOfScienceCategory | Immunology | - |
dc.relation.journalWebOfScienceCategory | Infectious Diseases | - |
dc.relation.journalWebOfScienceCategory | Microbiology | - |
dc.subject.keywordPlus | LONGITUDINAL ASSESSMENT | - |
dc.subject.keywordAuthor | antibody | - |
dc.subject.keywordAuthor | COVID-19 | - |
dc.subject.keywordAuthor | neutralizing activity | - |
dc.subject.keywordAuthor | SARS-CoV-2 | - |
dc.subject.keywordAuthor | variants of concern | - |
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