Osteogenic Efficacy of Human Trophoblasts-Derived Conditioned Medium on Mesenchymal Stem Cells
DC Field | Value | Language |
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dc.contributor.author | Go, Yoon-Young | - |
dc.contributor.author | Lee, Chan-Mi | - |
dc.contributor.author | Chae, Sung-Won | - |
dc.contributor.author | Song, Jae-Jun | - |
dc.date.accessioned | 2022-11-18T15:41:06Z | - |
dc.date.available | 2022-11-18T15:41:06Z | - |
dc.date.created | 2022-11-17 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1661-6596 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145774 | - |
dc.description.abstract | Trophoblasts play an important role in the regulation of the development and function of the placenta. Our recent study demonstrated the skin regeneration capacity of trophoblast-derived extracellular vesicles (EV). Here, we aimed to determine the potential of trophoblast-derived conditioned medium (TB-CM) in enhancing the osteogenic differentiation of bone marrow mesenchymal stem cells (MSCs). We found that TB-CM promoted the osteogenic differentiation of MSCs in a dose-dependent manner. Furthermore, it inhibited adipogenesis of MSCs. We also found that the primary trophoblast-derived conditioned medium (PTB-CM) significantly enhanced the proliferation and osteogenic differentiation of human MSCs. Our study demonstrated the regulatory mechanisms underlying the TB-CM-induced osteogenesis in MSCs. An upregulation of genes associated with cytokines/chemokines was observed. The treatment of MSCs with TB-CM stimulated osteogenesis by activating several biological processes, such as mitogen-activated protein kinase (MAPK) and bone morphogenetic protein 2 (BMP2) signaling. This study demonstrated the proliferative and osteogenic efficacies of the trophoblast-derived secretomes, suggesting their potential for use in clinical interventions for bone regeneration and treatment. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | OSTEOBLAST DIFFERENTIATION | - |
dc.subject | BONE-RESORPTION | - |
dc.subject | EXPRESSION | - |
dc.subject | MARROW | - |
dc.subject | BMP-2 | - |
dc.subject | STRINGTIE | - |
dc.subject | PATHWAY | - |
dc.subject | HISAT | - |
dc.title | Osteogenic Efficacy of Human Trophoblasts-Derived Conditioned Medium on Mesenchymal Stem Cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Song, Jae-Jun | - |
dc.identifier.doi | 10.3390/ijms231710196 | - |
dc.identifier.scopusid | 2-s2.0-85137580872 | - |
dc.identifier.wosid | 000851119300001 | - |
dc.identifier.bibliographicCitation | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, v.23, no.17 | - |
dc.relation.isPartOf | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.title | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | - |
dc.citation.volume | 23 | - |
dc.citation.number | 17 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Biochemistry & Molecular Biology | - |
dc.relation.journalResearchArea | Chemistry | - |
dc.relation.journalWebOfScienceCategory | Biochemistry & Molecular Biology | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Multidisciplinary | - |
dc.subject.keywordPlus | OSTEOBLAST DIFFERENTIATION | - |
dc.subject.keywordPlus | BONE-RESORPTION | - |
dc.subject.keywordPlus | EXPRESSION | - |
dc.subject.keywordPlus | MARROW | - |
dc.subject.keywordPlus | BMP-2 | - |
dc.subject.keywordPlus | STRINGTIE | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | HISAT | - |
dc.subject.keywordAuthor | human trophoblasts | - |
dc.subject.keywordAuthor | conditioned medium | - |
dc.subject.keywordAuthor | osteogenesis | - |
dc.subject.keywordAuthor | mesenchymal stem cells | - |
dc.subject.keywordAuthor | mitogen-activated protein kinase cascades | - |
dc.subject.keywordAuthor | chemokines | - |
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