Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation Targeting Restitution Parameter-Guided Catheter Ablation: CUVIA-REGAB Prospective Randomized Study
DC Field | Value | Language |
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dc.contributor.author | Choi, Young | - |
dc.contributor.author | Lim, Byounghyun | - |
dc.contributor.author | Yang, Song-Yi | - |
dc.contributor.author | Yang, So-Hyun | - |
dc.contributor.author | Kwon, Oh-Seok | - |
dc.contributor.author | Kim, Daehoon | - |
dc.contributor.author | Kim, Yun Gi | - |
dc.contributor.author | Park, Je-Wook | - |
dc.contributor.author | Yu, Hee Tae | - |
dc.contributor.author | Kim, Tae-Hoon | - |
dc.contributor.author | Yang, Pil-Sung | - |
dc.contributor.author | Uhm, Jae -Sun | - |
dc.contributor.author | Shim, Jamin | - |
dc.contributor.author | Kim, Sung Hwan | - |
dc.contributor.author | Sung, Jung-Hoon | - |
dc.contributor.author | Choi, Jong-il | - |
dc.contributor.author | Joung, Boyoung | - |
dc.contributor.author | Lee, Moon-Hyoung | - |
dc.contributor.author | Kim, Young-Hoon | - |
dc.contributor.author | Oh, Yong-Seog | - |
dc.contributor.author | Pak, Hui-Nam | - |
dc.contributor.author | CUVIA-REGAB Investigators | - |
dc.date.accessioned | 2022-11-18T16:40:58Z | - |
dc.date.available | 2022-11-18T16:40:58Z | - |
dc.date.created | 2022-11-17 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 1738-5520 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145777 | - |
dc.description.abstract | Background and Objectives: We investigated whether extra-pulmonary vein (PV) ablation targeting a high maximal slope of the action potential duration restitution curve (Smax) improves the rhythm outcome of persistent atrial fibrillation (PeAF) ablation. Methods: In this open-label, multi-center, randomized, and controlled trial, 178 PeAF patients were randomized with 1:1 ratio to computational modeling-guided virtual Smax ablation (V-Smax) or empirical ablation (E-ABL) groups. Smax maps were generated by computational modeling based on atrial substrate maps acquired during clinical procedures in sinus rhythm. Smax maps were generated during the clinical PV isolation (PVI). The V-Smax group underwent an additional extra-PV ablation after PVI targeting the virtual high Smax sites. Results: After a mean follow-up period of 12.3 +/- 5.2 months, the clinical recurrence rates (25.6% vs. 23.9% in the V-Smax and the E-ABL group, p=0.880) or recurrence appearing as atrial tachycardia (11.1% vs. 5.7%, p=0.169) did not differ between the 2 groups. The post -ablation cardioversion rate was higher in the V-Smax group than E-ABL group (14.4% vs. 5.7%, p=0.027). Among antiarrhythmic drug-free patients (n=129), the AF freedom rate was 78.7% in the V-Smax group and 80.9% in the E-ABL group (p=0.776). The total procedure time was longer in the V-Smax group (p=0.008), but no significant difference was found in the major complication rates (p=0.497) between the groups. Conclusions: Unlike a dominant frequency ablation, the computational modeling-guided V-Smax ablation did not improve the rhythm outcome of the PeAF ablation and had a longer procedure time. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | KOREAN SOC CARDIOLOGY | - |
dc.subject | REPOLARIZATION | - |
dc.subject | INITIATION | - |
dc.title | Clinical Usefulness of Virtual Ablation Guided Catheter Ablation of Atrial Fibrillation Targeting Restitution Parameter-Guided Catheter Ablation: CUVIA-REGAB Prospective Randomized Study | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Choi, Jong-il | - |
dc.identifier.doi | 10.4070/kcj.2022.0113 | - |
dc.identifier.scopusid | 2-s2.0-85135589198 | - |
dc.identifier.wosid | 000863317300005 | - |
dc.identifier.bibliographicCitation | KOREAN CIRCULATION JOURNAL, v.52, no.9, pp.699 - 711 | - |
dc.relation.isPartOf | KOREAN CIRCULATION JOURNAL | - |
dc.citation.title | KOREAN CIRCULATION JOURNAL | - |
dc.citation.volume | 52 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 699 | - |
dc.citation.endPage | 711 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002875237 | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.subject.keywordPlus | REPOLARIZATION | - |
dc.subject.keywordPlus | INITIATION | - |
dc.subject.keywordAuthor | Catheter ablation | - |
dc.subject.keywordAuthor | Computer simulation | - |
dc.subject.keywordAuthor | Action potential | - |
dc.subject.keywordAuthor | Electrophysiology | - |
dc.subject.keywordAuthor | Atrial fibrillation | - |
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