Association between High Lipid Burden of Target Lesion and Slow TIMI Flow in Coronary Interventions
DC Field | Value | Language |
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dc.contributor.author | Lim, Subin | - |
dc.contributor.author | Cha, Jung-Joon | - |
dc.contributor.author | Hong, Soon Jun | - |
dc.contributor.author | Kim, Ju Hyeon | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Park, Jae Hyoung | - |
dc.contributor.author | Yu, Cheol Woong | - |
dc.contributor.author | Ahn, Tae Hoon | - |
dc.contributor.author | Lim, Do-Sun | - |
dc.date.accessioned | 2022-11-18T19:40:26Z | - |
dc.date.available | 2022-11-18T19:40:26Z | - |
dc.date.created | 2022-11-17 | - |
dc.date.issued | 2022-09 | - |
dc.identifier.issn | 2077-0383 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/145790 | - |
dc.description.abstract | Decreased thrombolysis in myocardial infarction (TIMI) flow is associated with poor clinical outcomes. However, its predictors are not fully known. A combination of near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) could be used to detect lesions at high risk of slow TIMI flow. This study evaluated 636 consecutive patients undergoing target-lesion NIRS-IVUS imaging prior to percutaneous coronary intervention (PCI). The maximal lipid core burden index over 4-mm segments (maxLCBI(4mm)) per target vessel was calculated. The primary endpoint was the association between maxLCBI(4mm) and post-interventional TIMI flow. A high lipid core burden index (LCBI) cut-off point was determined using receiver-operating characteristic analysis. Decreased TIMI flow (TIMI less than 3) occurred in 90 patients and normal TIMI flow in 546 patients. The decreased TIMI flow group showed significantly higher incidence of cardiovascular events (5.6% vs. 1.5%, log-rank p = 0.010) in three months of composite events including cardiac death, myocardial infarction, stent thrombosis, and target lesion revascularization. In multivariable analysis, a high LCBI (>= 354) was independently associated with slow TIMI flow (OR, 2.59 (95% CI, 1.33-5.04), p = 0.005). High LCBI measured using NIRS-IVUS imaging was an independent predictor of decreased post-PCI TIMI flow. Performing PCI for high-LCBI lesions may necessitate adjunctive measures to prevent suboptimal post-PCI reperfusion. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | MDPI | - |
dc.subject | NEAR-INFRARED SPECTROSCOPY | - |
dc.subject | NO-REFLOW PHENOMENON | - |
dc.subject | RISK-ASSESSMENT STRATEGIES | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | VULNERABLE PATIENT | - |
dc.subject | PLAQUE RUPTURE | - |
dc.subject | DEFINITIONS | - |
dc.subject | THROMBOLYSIS | - |
dc.subject | EMBOLIZATION | - |
dc.subject | ULTRASOUND | - |
dc.title | Association between High Lipid Burden of Target Lesion and Slow TIMI Flow in Coronary Interventions | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Cha, Jung-Joon | - |
dc.contributor.affiliatedAuthor | Joo, Hyung Joon | - |
dc.identifier.doi | 10.3390/jcm11185401 | - |
dc.identifier.scopusid | 2-s2.0-85138618525 | - |
dc.identifier.wosid | 000859453900001 | - |
dc.identifier.bibliographicCitation | JOURNAL OF CLINICAL MEDICINE, v.11, no.18 | - |
dc.relation.isPartOf | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.title | JOURNAL OF CLINICAL MEDICINE | - |
dc.citation.volume | 11 | - |
dc.citation.number | 18 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | General & Internal Medicine | - |
dc.relation.journalWebOfScienceCategory | Medicine, General & Internal | - |
dc.subject.keywordPlus | NEAR-INFRARED SPECTROSCOPY | - |
dc.subject.keywordPlus | NO-REFLOW PHENOMENON | - |
dc.subject.keywordPlus | RISK-ASSESSMENT STRATEGIES | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | VULNERABLE PATIENT | - |
dc.subject.keywordPlus | PLAQUE RUPTURE | - |
dc.subject.keywordPlus | DEFINITIONS | - |
dc.subject.keywordPlus | THROMBOLYSIS | - |
dc.subject.keywordPlus | EMBOLIZATION | - |
dc.subject.keywordPlus | ULTRASOUND | - |
dc.subject.keywordAuthor | lipid core burden index | - |
dc.subject.keywordAuthor | near-infrared spectroscopy | - |
dc.subject.keywordAuthor | thrombolysis in myocardial infarction | - |
dc.subject.keywordAuthor | percutaneous coronary intervention | - |
dc.subject.keywordAuthor | intravascular ultrasound | - |
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