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Decreased cortical gyrification in patients with bipolar disorder

Authors
Choi, Kwan WooHan, Kyu-ManKim, AramKang, WooyoungKang, YoubinTae, Woo-SukHam, Byung-Joo
Issue Date
9월-2022
Publisher
CAMBRIDGE UNIV PRESS
Keywords
Bipolar disorder; brain magnetic resonance imaging; cortical folding; endophenotype; local gyrification index
Citation
PSYCHOLOGICAL MEDICINE, v.52, no.12, pp.2232 - 2244
Indexed
SCIE
SSCI
SCOPUS
Journal Title
PSYCHOLOGICAL MEDICINE
Volume
52
Number
12
Start Page
2232
End Page
2244
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/145804
DOI
10.1017/S0033291720004079
ISSN
0033-2917
Abstract
Background An aberrant neural connectivity has been known to be associated with bipolar disorder (BD). Local gyrification may reflect the early neural development of cortical connectivity and has been studied as a possible endophenotype of psychiatric disorders. This study aimed to investigate differences in the local gyrification index (LGI) in each cortical region between patients with BD and healthy controls (HCs). Methods LGI values, as measured using FreeSurfer software, were compared between 61 patients with BD and 183 HCs. The values were also compared between patients with BD type I and type II as a sub-group analysis. Furthermore, we evaluated whether there was a correlation between LGI values and illness duration or depressive symptom severity in patients with BD. Results Patients with BD showed significant hypogyria in various cortical regions, including the left inferior frontal gyrus (pars opercularis), precentral gyrus, postcentral gyrus, superior temporal cortex, insula, right entorhinal cortex, and both transverse temporal cortices, compared to HCs after the Bonferroni correction (p < 0.05/66, 0.000758). LGI was not associated with clinical factors such as illness duration, depressive symptom severity, and lithium treatment. No significant differences in cortical gyrification according to the BD subtype were found. Conclusions BD appears to be characterized by a significant regionally localized hypogyria, in various cortical areas. This abnormality may be a structural and developmental endophenotype marking the risk for BD, and it might help to clarify the etiology of BD.
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