Peripheral T cell lymphoma of the nasopharynx with expansion of EBV-positive B cells masquerading as an extranodal NK/T cell lymphoma, nasal type
- Authors
- Kim, Han-Na; Kim, Dae Sik; Jeon, Min Ji; Yu, Eun Sang; Choi, Chul-Won; Ko, Young Hyeh
- Issue Date
- 7월-2022
- Publisher
- SPRINGER
- Keywords
- Epstein-Barr virus; Extranodal NK/T cell lymphoma, Nasal-type; Bystander; B cell
- Citation
- VIRCHOWS ARCHIV, v.481, no.1, pp.125 - 129
- Indexed
- SCIE
SCOPUS
- Journal Title
- VIRCHOWS ARCHIV
- Volume
- 481
- Number
- 1
- Start Page
- 125
- End Page
- 129
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/145873
- DOI
- 10.1007/s00428-021-03240-0
- ISSN
- 0945-6317
- Abstract
- Epstein-Barr virus-infected B cells are found at high frequency in peripheral T cell lymphoma. Herein, we report a case involving excessive EBV-positive B cells accompanying peripheral T cell lymphoma, not otherwise specified in the nasopharynx masquerading as nasopharyngeal extranodal NK/T cell lymphoma. A large number of Epstein-Barr virus-infected B cells infiltrate in between CD3-positive cytotoxic tumor T cells, as if EBV was infecting tumor T cells. After chemotherapy, the T cell lymphoma population decreased, but the B cell population expanded to form EBV-positive diffuse large B cell lymphoma in the tonsils and nasopharynx. At the follow-up, bone marrow biopsy exhibited infiltration of composite peripheral T cell lymphoma, not otherwise specified, and EBV-positive diffuse large B cell lymphoma. Although this condition is rare, the cell lineage of EBV-infected cells must be confirmed when diagnosing extranodal NK/T cell lymphoma to exclude the possibility of misdiagnosis by Epstein-Barr virus-infected B cells.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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