Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Fluroxypyr-1-methylheptyl ester induced ROS production and mitochondrial apoptosis through the MAPK signaling cascade in porcine trophectoderm and uterine luminal epithelial cells

Authors
Kim, M.An, G.Lim, W.Song, G.
Issue Date
2022
Publisher
Academic Press Inc.
Keywords
Apoptosis; Fluroxypyr; Mitochondrial membrane potential; ROS production; Trophectoderm; Uterine luminal epithelial
Citation
Pesticide Biochemistry and Physiology, v.187
Indexed
SCIE
SCOPUS
Journal Title
Pesticide Biochemistry and Physiology
Volume
187
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/146041
DOI
10.1016/j.pestbp.2022.105196
ISSN
0048-3575
Abstract
FPMH (Fluroxypyr-1-methylheptyl ester) is a synthetic auxin herbicide used in agriculture. The mechanism by which FPMH induces adverse effects in porcine trophectoderm (pTr) and porcine uterine luminal epithelial (pLE) cells, which are involved in porcine implantation, have not been studied yet. Therefore, the present study investigates the toxicological effects of FPMH on pTr and pLE cells. We confirmed that FPMH induced cytotoxic effects on the cells, including apoptosis induction, mitochondrial membrane potential (MMP) depolarization, and ROS production. The phosphorylation of the MAPK pathway (ERK1/2, JNK, and p38) was dysregulated by FPMH administration. In addition, FPMH could suppress cell-cell adhesion and migration abilities of pTr and pLE, which are crucial for implantation. Therefore, exposure to FPMH induced adverse effects in pTr and pLE cells and could result in implantation failure. © 2022 Elsevier Inc.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biotechnology > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Song, Gwon hwa photo

Song, Gwon hwa
융합생명공학과
Read more

Altmetrics

Total Views & Downloads

BROWSE