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Hippocampal volume is related to olfactory impairment in Parkinson's disease

Authors
Roh, HaewonKang, JuneKoh, Seong-BeomKim, Jong Hyun
Issue Date
11월-2021
Publisher
WILEY
Keywords
cognition; hippocampus; hyposmia; olfactory; Parkinson' s disease
Citation
JOURNAL OF NEUROIMAGING, v.31, no.6, pp.1176 - 1183
Indexed
SCIE
SCOPUS
Journal Title
JOURNAL OF NEUROIMAGING
Volume
31
Number
6
Start Page
1176
End Page
1183
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/146102
DOI
10.1111/jon.12911
ISSN
1051-2284
Abstract
Background and Purpose Recent evidence has suggested that hyposmia in patients with Parkinson's disease (PD) may be due to impaired central processing. Furthermore, the hippocampus has been regarded as a critical structure linking olfactory impairment and cognitive impairment in PD patients. This study aimed to identify significant structural alterations of the hippocampus in PD patients with hyposmia, and to determine whether these structural changes are significantly associated with olfactory impairment severity. Methods Eighteen idiopathic PD patients with hyposmia and 18 age- and sex-matched PD patients without hyposmia were enrolled. Hippocampal volume and its subfields were measured using FreeSurfer software and compared between hyposmic and normosmic PD patients. We also compared hippocampal substructures' volumes and correlated the hippocampal volumes with hyposmia severity. Results PD patients with hyposmia had significantly smaller hippocampal volumes. Among the three components of the hippocampus, the hippocampal body showed a markedly lower volume, which correlated significantly with the cross-cultural smell identification test score that represents olfactory function status. Hippocampal subfield analysis showed that substructures (subiculum, molecular layer) that constitute the hippocampal body showed the most significant volume difference. Conclusions We suggest that atrophy of the bilateral hippocampus implies underlying problems in the central olfaction process in PD patients. In particular, the hippocampus might not only play a critical role in olfaction but could also be important for elucidating possible mechanisms of broad nonmotor symptoms in PD patients.
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