Comparison of the effects of triglyceride variability and exposure estimate on clinical prognosis in diabetic patients
DC Field | Value | Language |
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dc.contributor.author | Koh, Sung Min | - |
dc.contributor.author | Chung, Se Hwa | - |
dc.contributor.author | Yum, Yun Jin | - |
dc.contributor.author | Park, Se Jun | - |
dc.contributor.author | Joo, Hyung Joon | - |
dc.contributor.author | Kim, Yong-Hyun | - |
dc.contributor.author | Kim, Eung Ju | - |
dc.date.accessioned | 2022-12-08T16:41:41Z | - |
dc.date.available | 2022-12-08T16:41:41Z | - |
dc.date.created | 2022-12-08 | - |
dc.date.issued | 2022-11-15 | - |
dc.identifier.issn | 1475-2840 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/146496 | - |
dc.description.abstract | Background Hypertriglyceridemia is an important feature of dyslipidemia in type 1 and type 2 diabetic patients and associated with the development of atherosclerotic cardiovascular disease. Recently, variability of lipid profile has been suggested as a residual risk factor for cardiovascular disease. This study compared the clinical impact of serum triglyceride variability, and their cumulative exposure estimates on cardiovascular prognosis in diabetic patients. Methods A total of 25,933 diabetic patients who had serum triglyceride levels measured at least 3 times and did not have underlying malignancy, myocardial infarction (MI), and stroke during the initial 3 years (modeling phase) were selected from three tertiary hospitals. They were divided into a high/low group depending on their coefficient of variation (CV) and cumulative exposure estimate (CEE). Incidence of major adverse event (MAE), a composite of all-cause death, MI, and stroke during the following 5 years were compared between groups by multivariable analysis after propensity score matching. Results Although there was a slight difference, both the high CV group and the high CEE group had a higher cardiovascular risk profile including male-dominance, smoking, alcohol, dyslipidemia, and chronic kidney disease compared to the low groups. After the propensity score matching, the high CV group showed higher MAE incidence compared to the low CV group (9.1% vs 7.7%, p = 0.01). In contrast, there was no significant difference of MAE incidence between the high CEE group and the low CEE group (8.6% vs 9.1%, p = 0.44). After the multivariable analysis with further adjustment for potential residual confounding factors, the high CV was suggested as an independent risk predictor for MAE (HR 1.19 [95% CI 1.03-1.37]). Conclusion Visit-to-visit variability of triglyceride rather than their cumulative exposure is more strongly related to the incidence of MAE in diabetic patients. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | BMC | - |
dc.subject | CORONARY-HEART-DISEASE | - |
dc.subject | DENSITY-LIPOPROTEIN CHOLESTEROL | - |
dc.subject | TO-VISIT VARIABILITY | - |
dc.subject | CARDIOVASCULAR-DISEASE | - |
dc.subject | SECONDARY PREVENTION | - |
dc.subject | HDL-CHOLESTEROL | - |
dc.subject | MYOCARDIAL-INFARCTION | - |
dc.subject | SCIENTIFIC STATEMENT | - |
dc.subject | ARTERY-DISEASE | - |
dc.subject | RISK | - |
dc.title | Comparison of the effects of triglyceride variability and exposure estimate on clinical prognosis in diabetic patients | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Yong-Hyun | - |
dc.identifier.doi | 10.1186/s12933-022-01681-8 | - |
dc.identifier.scopusid | 2-s2.0-85142001534 | - |
dc.identifier.wosid | 000884274800001 | - |
dc.identifier.bibliographicCitation | CARDIOVASCULAR DIABETOLOGY, v.21, no.1 | - |
dc.relation.isPartOf | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.title | CARDIOVASCULAR DIABETOLOGY | - |
dc.citation.volume | 21 | - |
dc.citation.number | 1 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Cardiovascular System & Cardiology | - |
dc.relation.journalResearchArea | Endocrinology & Metabolism | - |
dc.relation.journalWebOfScienceCategory | Cardiac & Cardiovascular Systems | - |
dc.relation.journalWebOfScienceCategory | Endocrinology & Metabolism | - |
dc.subject.keywordPlus | CORONARY-HEART-DISEASE | - |
dc.subject.keywordPlus | DENSITY-LIPOPROTEIN CHOLESTEROL | - |
dc.subject.keywordPlus | TO-VISIT VARIABILITY | - |
dc.subject.keywordPlus | CARDIOVASCULAR-DISEASE | - |
dc.subject.keywordPlus | SECONDARY PREVENTION | - |
dc.subject.keywordPlus | HDL-CHOLESTEROL | - |
dc.subject.keywordPlus | MYOCARDIAL-INFARCTION | - |
dc.subject.keywordPlus | SCIENTIFIC STATEMENT | - |
dc.subject.keywordPlus | ARTERY-DISEASE | - |
dc.subject.keywordPlus | RISK | - |
dc.subject.keywordAuthor | Triglyceride | - |
dc.subject.keywordAuthor | Variability | - |
dc.subject.keywordAuthor | Cumulative exposure | - |
dc.subject.keywordAuthor | Major adverse event | - |
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