Impact of COVID-19 Pandemic on Management and Outcomes in Patients with Septic Shock in the Emergency Departmentopen access
- Authors
- Jeong, Daun; Lee, Gun Tak; Park, Jong Eun; Shin, Tae Gun; Kim, Kyunga; Jang, Doeun; Kim, Won Young; Jo, You Hwan; Chung, Sung Phil; Beom, Jin Ho; Choi, Sung-Hyuk; Kwon, Woon Yong; Suh, Gil Joon; Ko, Byuk Sung; Han, Kap Su; Shin, Jong Hwan; Cho, Hanjin; Hwang, Sung Yeon
- Issue Date
- 11월-2022
- Publisher
- MDPI
- Keywords
- COVID-19; septic shock; resuscitation; sepsis bundle; mortality
- Citation
- JOURNAL OF PERSONALIZED MEDICINE, v.12, no.11
- Indexed
- SCIE
SCOPUS
- Journal Title
- JOURNAL OF PERSONALIZED MEDICINE
- Volume
- 12
- Number
- 11
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/146529
- DOI
- 10.3390/jpm12111803
- ISSN
- 2075-4426
- Abstract
- This study aimed to determine the impact of modifications in emergency department (ED) practices caused by the coronavirus disease 2019 (COVID-19) pandemic on the clinical outcomes and management of patients with septic shock. We performed a retrospective study. Patients with septic shock who presented to the ED between 1 January 2018 and 19 January 2020 were allocated to the pre-COVID-19 group, whereas those who presented between 20 January 2020 and 31 December 2020 were assigned to the post-COVID-19 group. We used propensity score matching to compare the sepsis-related interventions and clinical outcomes. The primary outcome measure was in-hospital mortality. Of the 3697 patients included, 2254 were classified as pre-COVID-19 and 1143 as postCOVID-19. A total of 1140 propensity score-matched pairings were created. Overall, the in-hospital mortality rate was 25.5%, with no statistical difference between the pre- and post-COVID-19 groups (p = 0.92). In a matched cohort, the post-COVID-19 group had delayed lactate measurement, blood culture test, and infection source control (all p < 0.05). There was no significant difference in time to antibiotics (p = 0.19) or vasopressor administration (p = 0.09) between the groups. Although sepsis-related interventions were delayed during the COVID-19 pandemic, there was no significant difference in the in-hospital mortality between the pre- and post-COVID-19 groups.
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