Detailed Information

Cited 0 time in webofscience Cited 0 time in scopus
Metadata Downloads

Nuclear transport of STAT6 determines the matrix rigidity dependent M2 activation of macrophagesopen access

Authors
Kim, Jeong-KiHan, Seong-BeomPark, Serk InKim, In-SanKim, Dong-Hwee
Issue Date
11월-2022
Publisher
ELSEVIER SCI LTD
Keywords
M2 macrophage; STAT6; Nuclear transport; Mechanosensation; Nuclear mechanics; Mechanomodulation of immune response
Citation
BIOMATERIALS, v.290
Indexed
SCIE
SCOPUS
Journal Title
BIOMATERIALS
Volume
290
URI
https://scholar.korea.ac.kr/handle/2021.sw.korea/146533
DOI
10.1016/j.biomaterials.2022.121859
ISSN
0142-9612
Abstract
Alternatively activated or M2 macrophages, as opposed to the well characterized pro-inflammatory or M1 macrophages, vitally regulate anti-inflammation, wound healing, and tissue repair to maintain tissue homeostasis. Although ubiquitous presence of macrophages in diverse tissues, exposed to different physical environments, infers distinct immune responses of M2 macrophages with high phenotypic heterogeneity, the underlying mechanism of how the varying extracellular mechanical conditions alter their immunological activation remains unclear. Here, we demonstrate that M2 activation requires a threshold mechanical cue from the extracellular microenvironment, and matrix rigidity-dependent macrophage spreading is mediated by the F-actin formation that is essential to regulate mechanosensitive M2 activation of macrophages. We identified a new mechanosensing function of STAT6 (signal transducer and activator of transcription 6), a key transcription factor for M2 activation, whose intranuclear transportation is promoted by the rigid matrix that facilitates the F-actin formation. Our findings further highlight the critical role of mechanosensitive M2 activation of macrophages in long-term adaptation to the extracellular microenvironment by bridging nuclear mechanosensation and immune responses.
Files in This Item
There are no files associated with this item.
Appears in
Collections
Graduate School > Department of Biomedical Sciences > 1. Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

BROWSE