Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Studyopen accessFasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
- Other Titles
- Fasting Glucose Variability and the Risk of Dementia in Individuals with Diabetes: A Nationwide Cohort Study
- Authors
- 이다영; 김재영; 박상현; 박소영; 유지희; 서지아; 김남훈; 류혜진; 김신곤; 최경묵; 백세현; Han Kyung-do; 김난희
- Issue Date
- 11월-2022
- Publisher
- 대한당뇨병학회
- Keywords
- Alzheimer disease; Dementia; Dementia; vascular; Diabetes mellitus; Glucose
- Citation
- Diabetes and Metabolism Journal, v.46, no.6, pp.923 - 935
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- Diabetes and Metabolism Journal
- Volume
- 46
- Number
- 6
- Start Page
- 923
- End Page
- 935
- URI
- https://scholar.korea.ac.kr/handle/2021.sw.korea/146550
- DOI
- 10.4093/dmj.2021.0346
- ISSN
- 2233-6079
- Abstract
- Background: We investigated whether fasting glucose (FG) variability could predict the risk of dementia.Methods: This cohort study analyzed data from Koreans with diabetes after at least three health examinations by the Korean National Health Insurance Corporation between 2005 and 2010, which included at least one examination between 2009 and 2010. A total of 769,554 individuals were included, excluding those aged <40 years and those with dementia. FG variability was measured using the variability independent of the mean (FG-VIM). The incidence of dementia was defined by the International Classification of Diseases 10th Revision codes and prescription of anti-dementia medication and was subdivided into Alzheimer’s disease (AD) and vascular dementia (VD).Results: During the 6.9-year follow-up, 54,837, 41,032, and 6,892 cases of all-cause dementia, AD, and VD, respectively, were identified. Cox proportional regression analyses showed that as the FG-VIM quartile increased, the risk of dementia serially increased after adjustment for metabolic factors, income status, and diabetes-related characteristics, including the mean FG. Participants in FG-VIM quartile 4 showed a 18%, 19%, and 17% higher risk for all-cause dementia, AD, and VD, respectively, than those in quartile 1; this particularly included non-obese patients with a longer duration of diabetes, high FG levels, dyslipidemia, and those taking glucose-lowering medications. Conversely, the baseline FG status and dementia showed a U-shaped association.Conclusion: Increased FG variability over 5 years can predict the risk of dementia in individuals with diabetes in Korea. This finding was more pronounced in patients with less favorable metabolic profiles.
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Collections - College of Medicine > Department of Medical Science > 1. Journal Articles
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