Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique
DC Field | Value | Language |
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dc.contributor.author | Han, Jun-Hyeok | - |
dc.contributor.author | Lee, Yun Young | - |
dc.contributor.author | Shin, Ha Eun | - |
dc.contributor.author | Han, Jieun | - |
dc.contributor.author | Kang, Jeon Min | - |
dc.contributor.author | Wang, Chi-Pin James | - |
dc.contributor.author | Park, Jung-Hoon | - |
dc.contributor.author | Kim, Se-Na | - |
dc.contributor.author | Yoon, Jong-Hwi | - |
dc.contributor.author | Kwon, Ho-Keun | - |
dc.contributor.author | Park, Dae-Hwan | - |
dc.contributor.author | Park, Tae-Eun | - |
dc.contributor.author | Choy, Young Bin | - |
dc.contributor.author | Kim, Dong-Hyun | - |
dc.contributor.author | Kim, Tae-Hyung | - |
dc.contributor.author | Min, Junhong | - |
dc.contributor.author | Kim, Ik-Hwan | - |
dc.contributor.author | Park, Chun Gwon | - |
dc.contributor.author | Han, Dong Keun | - |
dc.contributor.author | Park, Wooram | - |
dc.date.accessioned | 2022-12-09T08:00:22Z | - |
dc.date.available | 2022-12-09T08:00:22Z | - |
dc.date.created | 2022-12-08 | - |
dc.date.issued | 2022-10 | - |
dc.identifier.issn | 0142-9612 | - |
dc.identifier.uri | https://scholar.korea.ac.kr/handle/2021.sw.korea/146570 | - |
dc.description.abstract | Cancer immunotherapy is a next-generation treatment strategy; however, its side effects limit its clinical translation. Here, a novel combination of a multi-functional nano-adjuvant (M-NA) prepared with an iron oxide/ gold core and a cationic polymer shell via multilayer synthesis with CpG oligodeoxynucleotide (CpG-ODN) electrostatically complexed on its surface, and irreversible electroporation (IRE) technique was developed for effective image-guided in situ cancer vaccination. The M-NA can be retained long-term in the dense tumoral extracellular matrix after intratumoral injection and internalized by antigen-presenting cells (APCs). The IRE can induce immunogenic cell death. Indeed, in a mouse tumor model, the M-NA showed longer tumor retention time than free CpG-ODN. Compared with other treatments, the combined treatment significantly inhibited tumor growth with 100% survival rate for-60 days. The therapy induced the activation of cytotoxic lymphocytes and the maturation of APCs in vivo. This treatment could be effective in image-guided local cancer immunotherapy. | - |
dc.language | English | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCI LTD | - |
dc.subject | IMMUNOGENIC CELL-DEATH | - |
dc.subject | CYTOKINE PRODUCTION | - |
dc.subject | PHASE-I | - |
dc.subject | IMMUNOTHERAPY | - |
dc.subject | TUMOR | - |
dc.subject | CPG | - |
dc.subject | NANOPARTICLES | - |
dc.subject | IPILIMUMAB | - |
dc.subject | NIVOLUMAB | - |
dc.subject | ABLATION | - |
dc.title | Image-guided in situ cancer vaccination with combination of multi-functional nano-adjuvant and an irreversible electroporation technique | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Kim, Ik-Hwan | - |
dc.identifier.doi | 10.1016/j.biomaterials.2022.121762 | - |
dc.identifier.scopusid | 2-s2.0-85137033815 | - |
dc.identifier.wosid | 000855945200002 | - |
dc.identifier.bibliographicCitation | BIOMATERIALS, v.289 | - |
dc.relation.isPartOf | BIOMATERIALS | - |
dc.citation.title | BIOMATERIALS | - |
dc.citation.volume | 289 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Engineering | - |
dc.relation.journalResearchArea | Materials Science | - |
dc.relation.journalWebOfScienceCategory | Engineering, Biomedical | - |
dc.relation.journalWebOfScienceCategory | Materials Science, Biomaterials | - |
dc.subject.keywordPlus | IMMUNOGENIC CELL-DEATH | - |
dc.subject.keywordPlus | CYTOKINE PRODUCTION | - |
dc.subject.keywordPlus | PHASE-I | - |
dc.subject.keywordPlus | IMMUNOTHERAPY | - |
dc.subject.keywordPlus | TUMOR | - |
dc.subject.keywordPlus | CPG | - |
dc.subject.keywordPlus | NANOPARTICLES | - |
dc.subject.keywordPlus | IPILIMUMAB | - |
dc.subject.keywordPlus | NIVOLUMAB | - |
dc.subject.keywordPlus | ABLATION | - |
dc.subject.keywordAuthor | Cancer immunotherapy | - |
dc.subject.keywordAuthor | Multi-functional nano-adjuvant | - |
dc.subject.keywordAuthor | Irreversible electroporation | - |
dc.subject.keywordAuthor | Image-guided cancer therapy | - |
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